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Length of Epstein-Barr Virus Termini as a Determinant of Epithelial Cell Clonal Emergence

Department of Microbiology and Immunology,¹ Feist-Weiller Cancer Center, Louisiana State University Health Sciences Center, Shreveport, Louisiana²

Received 16 December 2002/ Accepted 3 May 2003

Reiterated terminal sequences of Epstein-Barr virus (EBV) DNA are numerically heterogeneous among infectious virions, providing a viral measure of clonality in infected cells. After in vitro infection, carcinoma cells bearing EBV episomes with fewer terminal repeats (TRs) proliferated faster. In single-cell clones, TR number varied inversely to the quantity of latent membrane protein 2A (LMP2A) transcripts whose unspliced precursors cross joined TRs. Thus, EBV clonality may reflect selection for a TR number that optimizes LMP2A-enhanced tumor progression, with infection occurring after epithelial cell transformation.

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