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Journal of Virology, July 2003, p. 8166-8172, Vol. 77, No. 14
0022-538X/03/$08.00+0     DOI: 10.1128/JVI.77.14.8166-8172.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Differential Hyperacetylation of Histones H3 and H4 upon Promoter-Specific Recruitment of EBNA2 in Epstein-Barr Virus Chromatin

Nathalie Alazard, Henri Gruffat, Edwige Hiriart, Alain Sergeant, and Evelyne Manet*

Unité de Virologie Humaine, U412 INSERM, Ecole Normale Supérieure de Lyon, 69364 Lyon Cedex 07, France

Received 28 February 2003/ Accepted 28 April 2003

Epstein-Barr virus nuclear antigen 2 (EBNA2) is a transcriptional activator involved in the immortalization of B lymphocytes by the virus. EBNA2 is targeted to the promoters of its responsive genes, via interaction with cellular DNA-binding proteins. Using chromatin immunoprecipitation assays, we show for the first time the conditional recruitment of EBNA2 on two specific viral promoters in vivo and demonstrate a correlation between this recruitment and a local change in the acetylation of histones H3 and H4, which is promoter dependent.

* Corresponding author. Mailing address: Unité de Virologie Humaine, U412 INSERM, Ecole Normale Supérieure de Lyon, 46 Allée d'Italie, 69364 Lyon Cedex 07, France. Phone: 33-472-72-81-76. Fax: 33-472-72-80-80. E-mail: emanet{at}ens-lyon.fr.

Journal of Virology, July 2003, p. 8166-8172, Vol. 77, No. 14
0022-538X/03/$08.00+0     DOI: 10.1128/JVI.77.14.8166-8172.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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