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Journal of Virology, July 2003, p. 7673-7676, Vol. 77, No. 13
0022-538X/03/$08.00+0     DOI: 10.1128/JVI.77.13.7673-7676.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Coexistence of Two Distinct Secretion Mutations (P5T and I97L) in Hepatitis B Virus Core Produces a Wild-Type Pattern of Secretion

Pong Kian Chua,1 Yu-Mei Wen,2 and Chiaho Shih1*

Center for Tropical Diseases, Department of Pathology, and Department of Microbiology & Immunology, University of Texas Medical Branch, Galveston, Texas 77555-0609,1 Department of Molecular Virology, Medical Center of Fudan University, Shanghai 200032, People's Republic of China2

Received 23 January 2003/ Accepted 2 April 2003

Unlike a Tokyo isolate of hepatitis B virus variants, we found a Shanghai isolate that secretes few virions with an immature genome despite its core I97L mutation. Core mutations P5T and I97L were found to be mutually compensatory in offsetting their respective distinct effects on virion secretion.

* Corresponding author. Mailing address: Center for Tropical Diseases, Department of Pathology, and Department of Microbiology & Immunology, University of Texas Medical Branch, Galveston, TX 77555-0609. Phone: (409) 772-2563. Fax: (409) 747-2429. E-mail: cshih{at}utmb.edu.

Journal of Virology, July 2003, p. 7673-7676, Vol. 77, No. 13
0022-538X/03/$08.00+0     DOI: 10.1128/JVI.77.13.7673-7676.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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