This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Chua, P. K. Articles by Shih, C. Search for Related Content PubMed PubMed Citation Articles by Chua, P. K. Articles by Shih, C.

Coexistence of Two Distinct Secretion Mutations (P5T and I97L) in Hepatitis B Virus Core Produces a Wild-Type Pattern of Secretion

Center for Tropical Diseases, Department of Pathology, and Department of Microbiology & Immunology, University of Texas Medical Branch, Galveston, Texas 77555-0609,¹ Department of Molecular Virology, Medical Center of Fudan University, Shanghai 200032, People's Republic of China²

Received 23 January 2003/ Accepted 2 April 2003

Unlike a Tokyo isolate of hepatitis B virus variants, we found a Shanghai isolate that secretes few virions with an immature genome despite its core I97L mutation. Core mutations P5T and I97L were found to be mutually compensatory in offsetting their respective distinct effects on virion secretion.

This article has been cited by other articles:

• Chua, P. K., Wang, R. Y.-L., Lin, M.-H., Masuda, T., Suk, F.-M., Shih, C. (2005). Reduced Secretion of Virions and Hepatitis B Virus (HBV) Surface Antigen of a Naturally Occurring HBV Variant Correlates with the Accumulation of the Small S Envelope Protein in the Endoplasmic Reticulum and Golgi Apparatus. J. Virol. 79: 13483-13496 [Abstract] [Full Text]  
• Roseman, A. M., Berriman, J. A., Wynne, S. A., Butler, P. J. G., Crowther, R. A. (2005). A structural model for maturation of the hepatitis B virus core. Proc. Natl. Acad. Sci. USA 102: 15821-15826 [Abstract] [Full Text]  
• Le Pogam, S., Chua, P. K., Newman, M., Shih, C. (2005). Exposure of RNA Templates and Encapsidation of Spliced Viral RNA Are Influenced by the Arginine-Rich Domain of Human Hepatitis B Virus Core Antigen (HBcAg 165-173). J. Virol. 79: 1871-1887 [Abstract] [Full Text]  
• Ning, B., Shih, C. (2004). Nucleolar Localization of Human Hepatitis B Virus Capsid Protein. J. Virol. 78: 13653-13668 [Abstract] [Full Text]  
• Khan, N., Guarnieri, M., Ahn, S. H., Li, J., Zhou, Y., Bang, G., Kim, K.-H., Wands, J. R., Tong, S. (2004). Modulation of Hepatitis B Virus Secretion by Naturally Occurring Mutations in the S Gene. J. Virol. 78: 3262-3270 [Abstract] [Full Text]  
• Newman, M., Suk, F.-M., Cajimat, M., Chua, P. K., Shih, C. (2003). Stability and Morphology Comparisons of Self-Assembled Virus-Like Particles from Wild-Type and Mutant Human Hepatitis B Virus Capsid Proteins. J. Virol. 77: 12950-12960 [Abstract] [Full Text]