This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Chua, P. K.
Right arrow Articles by Shih, C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Chua, P. K.
Right arrow Articles by Shih, C.

 Previous Article  |  Next Article 

Journal of Virology, July 2003, p. 7673-7676, Vol. 77, No. 13
0022-538X/03/$08.00+0     DOI: 10.1128/JVI.77.13.7673-7676.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Coexistence of Two Distinct Secretion Mutations (P5T and I97L) in Hepatitis B Virus Core Produces a Wild-Type Pattern of Secretion

Pong Kian Chua,1 Yu-Mei Wen,2 and Chiaho Shih1*

Center for Tropical Diseases, Department of Pathology, and Department of Microbiology & Immunology, University of Texas Medical Branch, Galveston, Texas 77555-0609,1 Department of Molecular Virology, Medical Center of Fudan University, Shanghai 200032, People's Republic of China2

Received 23 January 2003/ Accepted 2 April 2003

Unlike a Tokyo isolate of hepatitis B virus variants, we found a Shanghai isolate that secretes few virions with an immature genome despite its core I97L mutation. Core mutations P5T and I97L were found to be mutually compensatory in offsetting their respective distinct effects on virion secretion.


* Corresponding author. Mailing address: Center for Tropical Diseases, Department of Pathology, and Department of Microbiology & Immunology, University of Texas Medical Branch, Galveston, TX 77555-0609. Phone: (409) 772-2563. Fax: (409) 747-2429. E-mail: cshih{at}utmb.edu.


Journal of Virology, July 2003, p. 7673-7676, Vol. 77, No. 13
0022-538X/03/$08.00+0     DOI: 10.1128/JVI.77.13.7673-7676.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.




This article has been cited by other articles:

  • Crowther, R.A (2008). The Leeuwenhoek lecture 2006. Microscopy goes cold: frozen viruses reveal their structural secrets. Phil Trans R Soc B 363: 2441-2451 [Abstract] [Full Text]  
  • Chua, P. K., Wang, R. Y.-L., Lin, M.-H., Masuda, T., Suk, F.-M., Shih, C. (2005). Reduced Secretion of Virions and Hepatitis B Virus (HBV) Surface Antigen of a Naturally Occurring HBV Variant Correlates with the Accumulation of the Small S Envelope Protein in the Endoplasmic Reticulum and Golgi Apparatus. J. Virol. 79: 13483-13496 [Abstract] [Full Text]  
  • Roseman, A. M., Berriman, J. A., Wynne, S. A., Butler, P. J. G., Crowther, R. A. (2005). A structural model for maturation of the hepatitis B virus core. Proc. Natl. Acad. Sci. USA 102: 15821-15826 [Abstract] [Full Text]  
  • Le Pogam, S., Chua, P. K., Newman, M., Shih, C. (2005). Exposure of RNA Templates and Encapsidation of Spliced Viral RNA Are Influenced by the Arginine-Rich Domain of Human Hepatitis B Virus Core Antigen (HBcAg 165-173). J. Virol. 79: 1871-1887 [Abstract] [Full Text]  
  • Ning, B., Shih, C. (2004). Nucleolar Localization of Human Hepatitis B Virus Capsid Protein. J. Virol. 78: 13653-13668 [Abstract] [Full Text]  
  • Khan, N., Guarnieri, M., Ahn, S. H., Li, J., Zhou, Y., Bang, G., Kim, K.-H., Wands, J. R., Tong, S. (2004). Modulation of Hepatitis B Virus Secretion by Naturally Occurring Mutations in the S Gene. J. Virol. 78: 3262-3270 [Abstract] [Full Text]  
  • Newman, M., Suk, F.-M., Cajimat, M., Chua, P. K., Shih, C. (2003). Stability and Morphology Comparisons of Self-Assembled Virus-Like Particles from Wild-Type and Mutant Human Hepatitis B Virus Capsid Proteins. J. Virol. 77: 12950-12960 [Abstract] [Full Text]