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Journal of Virology, June 2003, p. 7139-7142, Vol. 77, No. 12
0022-538X/03/$08.00+0     DOI: 10.1128/JVI.77.12.7139-7142.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Cross-Reactivity of HLA-B*1801-Restricted T-Lymphocyte Clones with Target Cells Expressing Variants of the Human Cytomegalovirus 72kDa-IE1 Protein

Virginie Prod'homme, Christelle Retière, Ralitza Valtcheva, Marc Bonneville, and Marie-Martine Hallet*

Institut National de la Santé et de la Recherche Médicale U463, Institut de Biologie, 44093 Nantes Cedex 1, France

Received 8 November 2002/ Accepted 24 March 2003

The impact of natural polymorphism in a cytomegalovirus-dominant HLA-B*1801-restricted epitope, IE1199-206, on the specific responses of T-cell clones was assessed by measuring their cytolytic activity against target cells expressing mutated recombinant IE1 proteins. Our results suggest an in vivo selection of T lymphocytes that cross-react with multiple IE1 variants.

* Corresponding author. Mailing address: INSERM U463, Institut de Biologie, 9 quai Moncousu, 44093 Nantes Cedex 1, France. Phone: (33) 02 40 08 47 47. Fax: (33) 02 40 35 66 97. E-mail: mmhallet{at}nantes.inserm.fr.

Journal of Virology, June 2003, p. 7139-7142, Vol. 77, No. 12
0022-538X/03/$08.00+0     DOI: 10.1128/JVI.77.12.7139-7142.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.





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