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Journal of Virology, June 2003, p. 6580-6584, Vol. 77, No. 11
0022-538X/03/$08.00+0     DOI: 10.1128/JVI.77.11.6580-6584.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

The G Glycoprotein of Respiratory Syncytial Virus Depresses Respiratory Rates through the CX3C Motif and Substance P

Ralph A. Tripp,1* Azzeddine Dakhama,2 Les P. Jones,1 Albert Barskey,1 Erwin W. Gelfand,2 and Larry J. Anderson1

Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333,1 Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado 802062

Received 31 October 2002/ Accepted 6 March 2003

Respiratory syncytial virus (RSV) infection in the neonate can alter respiratory rates, i.e., lead to episodes of apnea. We show that RSV G glycoprotein reduces respiratory rates associated with the induction of substance P (SP) and G glycoprotein-CX3CR1 interaction, an effect that is inhibited by treatment with anti-G glycoprotein, anti-SP, or anti-CX3CR1 monoclonal antibodies. These data suggest new approaches for treating some aspects of RSV disease.

* Corresponding author. Mailing address: Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Rd., Atlanta, GA 30333. Phone: (404) 639-0753. Fax: (404) 639-4005. E-mail: RTripp{at}cdc.gov.

Journal of Virology, June 2003, p. 6580-6584, Vol. 77, No. 11
0022-538X/03/$08.00+0     DOI: 10.1128/JVI.77.11.6580-6584.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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