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Journal of Virology, May 2003, p. 6062-6065, Vol. 77, No. 10
0022-538X/03/$08.00+0     DOI: 10.1128/JVI.77.10.6062-6065.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Construction of Varicella-Zoster Virus Recombinants from Parent Oka Cosmids and Demonstration that ORF65 Protein Is Dispensable for Infection of Human Skin and T Cells in the SCID-hu Mouse Model

Takahiro Niizuma, Leigh Zerboni, Marvin H. Sommer, Hideki Ito, Stewart Hinchliffe, and Ann M. Arvin*

Departments of Pediatrics and Microbiology, Stanford University School of Medicine, Stanford, California 94305

Received 12 December 2002/ Accepted 25 February 2003

We generated an ORF65 deletion mutant by using a cosmid system constructed from the genome of a low-passage clinical isolate (P-Oka). Using the SCID-hu mouse model, we demonstrated that the ORF65 protein is dispensable for viral replication in skin and T cells, which are critical host cell targets during primary varicella-zoster virus infection.

* Corresponding author. Mailing address: G-311, Stanford University School of Medicine, 300 Pasteur Dr., Stanford, CA 94305. Phone: (650) 498-6227. Fax: (650) 725-8040. E-mail: aarvin{at}stanford.edu.

Journal of Virology, May 2003, p. 6062-6065, Vol. 77, No. 10
0022-538X/03/$08.00+0     DOI: 10.1128/JVI.77.10.6062-6065.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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