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Journal of Virology, January 2003, p. 804-809, Vol. 77, No. 1
0022-538X/03/$08.00+0     DOI: 10.1128/JVI.77.1.804-809.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Genetic Interaction between Distinct Dobrava Hantavirus Subtypes in Apodemus agrarius and A. flavicollis in Nature

Boris Klempa,1,2 Heiko A. Schmidt,3 Rainer Ulrich,1 Stefan Kaluz,2,{dagger} Milan Labuda,4 Helga Meisel,1 Brian Hjelle,5 and Detlev H. Krüger1*

Institute of Virology, Charité School of Medicine, Humboldt University, D-10098 Berlin,1 Max Planck Institute of Molecular Genetics, D-14195 Berlin, Germany,3 Institute of Virology,2 Institute of Zoology, Slovak Academy of Sciences, 84206 Bratislava, Slovakia,4 Center for Emerging Infectious Diseases, Department of Pathology, University of New Mexico, Albuquerque, New Mexico 87131-52235

Received 11 July 2002/ Accepted 16 September 2002

Dobrava virus (DOBV) occurs in two different rodent species, Apodemus flavicollis (DOBV-Af) and A. agrarius (DOBV-Aa). We sequenced the S and M genomic segments from sympatric DOBV-Af and DOBV-Aa strains which fell into two distinct genetic lineages. Molecular phylogenetic analyses gave evidence for genetic reassortment between S and M segments of DOBV-Af and DOBV-Aa and indicated homologous recombination events in DOBV evolution. DOBV-Af and DOBV-Aa are distinct but also subject to genetic exchanges that affect their evolutionary trajectories.

* Corresponding author. Mailing address: Institute of Virology, Charité School of Medicine, Humboldt University, D-10098 Berlin, Germany. Phone: 49-30-450 525 092. Fax: 49-30-450 525 907. E-mail: detlev.kruger{at}charite.de.

{dagger} Present address: Department of Microbiology and Molecular Genetics, University of California at Irvine, Irvine, CA 92697-4025.

Journal of Virology, January 2003, p. 804-809, Vol. 77, No. 1
0022-538X/03/$08.00+0     DOI: 10.1128/JVI.77.1.804-809.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.





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