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Journal of Virology, May 2002, p. 4671-4677, Vol. 76, No. 9
0022-538X/02/$04.00+0     DOI: 10.1128/JVI.76.9.4671-4677.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Cyclophilin A Plays Distinct Roles in Human Immunodeficiency Virus Type 1 Entry and Postentry Events, as Revealed by Spinoculation{dagger}

Andrew C. S. Saphire, Michael D. Bobardt, and Philippe A. Gallay*

Department of Immunology, The Scripps Research Institute, La Jolla, California 92037

Received 29 October 2001/ Accepted 17 January 2002

Cyclophilin A (CypA) is necessary for effective human immunodeficiency virus type 1 (HIV-1) replication. However, the functions of CypA and the precise steps at which CypA acts in the HIV-1 life cycle remain to be determined. By using a methodology that bypasses the need for attachment factors—spinoculation—we present evidence that CypA participates in both entry and postentry events.

* Corresponding author. Mailing address: Department of Immunology IMM-9, The Scripps Research Institute, 10550 N. Torrey Pines Rd., La Jolla, CA 92037. Phone: (858) 784-8180. Fax: (858) 784-8227. E-mail: gallay{at}scripps.edu.

{dagger} This is publication no. 14317-IMM from the Department of Immunology, The Scripps Research Institute, La Jolla, Calif.

Journal of Virology, May 2002, p. 4671-4677, Vol. 76, No. 9
0022-538X/02/$04.00+0     DOI: 10.1128/JVI.76.9.4671-4677.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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