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Journal of Virology, May 2002, p. 4649-4650, Vol. 76, No. 9
0022-538X/02/$04.00+0     DOI: 10.1128/JVI.76.9.4649-4650.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Scrapie Infectivity in Hamster Blood Is Not Associated with Platelets

Karel Holada,1 Jaroslav G. Vostal,1 Patrick W. Theisen,2 Claudia MacAuley,2 Luisa Gregori,2 and Robert G. Rohwer2*

Laboratory of Cellular Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892,1 Molecular Neurovirology Laboratory, Department of Veterans Affairs Medical Center, Baltimore, Maryland 212012

Received 24 October 2001/ Accepted 17 January 2002

The infectivity of hamster scrapie strain 263K was measured in platelets isolated from blood pooled from six hamsters with clinical scrapie. The total number of infectious doses present in the blood pool was 220, out of which only 3.5 infectious doses were associated with platelets. A larger proportion of the total infectivity was recovered from the mononuclear leukocyte fraction. This result indicates that platelets are not the source of blood-borne infectivity in transmissible spongiform encephalopathy-infected hamsters.

* Corresponding author. Mailing address: Molecular Neurovirology Laboratory, Medical Research Service 151, VA Medical Center, 10 N. Greene St., Baltimore, MD 21201. Phone: (410) 605-7000, ext. 6462. Fax: (410) 605-7959. E-mail: rrohwer{at}umaryland.edu.

Journal of Virology, May 2002, p. 4649-4650, Vol. 76, No. 9
0022-538X/02/$04.00+0     DOI: 10.1128/JVI.76.9.4649-4650.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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