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Journal of Virology, May 2002, p. 4275-4286, Vol. 76, No. 9
0022-538X/02/$04.00+0     DOI: 10.1128/JVI.76.9.4275-4286.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Avian bic, a Gene Isolated from a Common Retroviral Site in Avian Leukosis Virus-Induced Lymphomas That Encodes a Noncoding RNA, Cooperates with c-myc in Lymphomagenesis and Erythroleukemogenesis

Wayne Tam,1,2,3* Stephen H. Hughes,4 William S. Hayward,1,2 and Peter Besmer1,2

Graduate Program in Molecular Biology,1 Department of Pathology, Joan & Sanford Weill Graduate School of Medical Sciences of Cornell University,3 Molecular Biology Program, Sloan-Kettering Institute for Cancer Research, Memorial Sloan-Kettering Cancer Center, New York, New York 10021,2 ABL-Basic Research Program, NCI Frederick Cancer Research and Development Center, Frederick, Maryland 21702-12014

Received 1 August 2001/ Accepted 25 January 2002

bic is a novel gene identified at a common retroviral integration site in avian leukosis virus-induced lymphomas and has been implicated as a collaborator with c-myc in B lymphomagenesis. It lacks an extensive open reading frame and is believed to function as an untranslated RNA (W. Tam, Gene 274:157-167, 2001; W. Tam, D. Ben-Yehuda, and W. S. Hayward, Mol. Cell. Biol. 17:1490-1502, 1997). The oncogenic potential of bic, particularly its ability to cooperate with c-myc in oncogenesis, was tested directly by expressing c-myc and bic, either singly or in pairwise combination, in cultured chicken embryo fibroblasts (CEFs) and in chickens using replication-competent retrovirus vectors. Coexpression of c-myc and bic in CEFs caused growth enhancement of cells. Most importantly, chick oncogenicity assays demonstrated that bic can cooperate with c-myc in lymphomagenesis and erythroleukemogenesis. The present study provides direct evidence for the involvement of untranslated RNAs in oncogenesis and provides further support for the role of noncoding RNAs as riboregulators.

* Corresponding author. Mailing address: Department of Pathology, Joan & Sanford I. Weill Medical College of Cornell University, K-508, 525 E. 68th St., New York, NY 10021. Phone: (212) 746-6486. Fax: (212) 746-8345. E-mail: wtam{at} med.cornell.edu.

Journal of Virology, May 2002, p. 4275-4286, Vol. 76, No. 9
0022-538X/02/$04.00+0     DOI: 10.1128/JVI.76.9.4275-4286.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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