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 Previous Article

Journal of Virology, April 2002, p. 4145-4151, Vol. 76, No. 8
0022-538X/02/$04.00+0     DOI: 10.1128/JVI.76.8.4145-4151.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Identification of Human Herpesvirus 6 Latency-Associated Transcripts

Kazuhiro Kondo,1* Kazuya Shimada,1 Junji Sashihara,2 Keiko Tanaka-Taya,2 and Koichi Yamanishi1

Department of Microbiology,1 Department of Pediatrics, Osaka University Medical School, Suita-City, Osaka 565-0871, Japan2

Received 9 July 2001/ Accepted 15 January 2002

Four kinds of latency-associated transcripts of human herpesvirus 6 were identified which were detected only in latently infected cells. Although they were oriented in the same direction as the immediate-early 1 and 2 (IE1/IE2) genes and shared their protein-coding region with IE1/IE2, their transcription start sites and exon(s) were latency associated.

* Corresponding author. Mailing address: Department of Microbiology, Osaka University Medical School C1, 2-2 Yamada-Oka, Suita-City, Osaka 565-0871, Japan. Phone: 816-6879-3323. Fax: 816-6879-3329. E-mail: kkondo{at}micro.med.osaka-u.ac.jp.

Journal of Virology, April 2002, p. 4145-4151, Vol. 76, No. 8
0022-538X/02/$04.00+0     DOI: 10.1128/JVI.76.8.4145-4151.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • De Bolle, L., Naesens, L., De Clercq, E. (2005). Update on Human Herpesvirus 6 Biology, Clinical Features, and Therapy. Clin. Microbiol. Rev. 18: 217-245 [Abstract] [Full Text]  
  • Kondo, K., Nozaki, H., Shimada, K., Yamanishi, K. (2003). Detection of a Gene Cluster That Is Dispensable for Human Herpesvirus 6 Replication and Latency. J. Virol. 77: 10719-10724 [Abstract] [Full Text]  
  • Kondo, K., Sashihara, J., Shimada, K., Takemoto, M., Amo, K., Miyagawa, H., Yamanishi, K. (2003). Recognition of a Novel Stage of Betaherpesvirus Latency in Human Herpesvirus 6. J. Virol. 77: 2258-2264 [Abstract] [Full Text]  
  • Dockrell, D.H. (2003). Human herpesvirus 6: molecular biology and clinical features. J Med Microbiol 52: 5-18 [Abstract] [Full Text]  
  • Stanton, R., Fox, J. D., Caswell, R., Sherratt, E., Wilkinson, G. W. G. (2002). Analysis of the human herpesvirus-6 immediate-early 1 protein. J. Gen. Virol. 83: 2811-2820 [Abstract] [Full Text]  


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