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Journal of Virology, April 2002, p. 4145-4151, Vol. 76, No. 8
0022-538X/02/$04.00+0     DOI: 10.1128/JVI.76.8.4145-4151.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Identification of Human Herpesvirus 6 Latency-Associated Transcripts

Kazuhiro Kondo,1* Kazuya Shimada,1 Junji Sashihara,2 Keiko Tanaka-Taya,2 and Koichi Yamanishi1

Department of Microbiology,1 Department of Pediatrics, Osaka University Medical School, Suita-City, Osaka 565-0871, Japan2

Received 9 July 2001/ Accepted 15 January 2002

Four kinds of latency-associated transcripts of human herpesvirus 6 were identified which were detected only in latently infected cells. Although they were oriented in the same direction as the immediate-early 1 and 2 (IE1/IE2) genes and shared their protein-coding region with IE1/IE2, their transcription start sites and exon(s) were latency associated.

* Corresponding author. Mailing address: Department of Microbiology, Osaka University Medical School C1, 2-2 Yamada-Oka, Suita-City, Osaka 565-0871, Japan. Phone: 816-6879-3323. Fax: 816-6879-3329. E-mail: kkondo{at}micro.med.osaka-u.ac.jp.

Journal of Virology, April 2002, p. 4145-4151, Vol. 76, No. 8
0022-538X/02/$04.00+0     DOI: 10.1128/JVI.76.8.4145-4151.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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