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Journal of Virology, April 2002, p. 4113-4118, Vol. 76, No. 8
0022-538X/02/$04.00+0     DOI: 10.1128/JVI.76.8.4113-4118.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Nucleoprotein Structure of Immediate-Early Promoters Zp and Rp and of oriLyt of Latent Epstein-Barr Virus Genomes

Hans Helmut Niller,1* Daniel Salamon,1,2 Jörg Uhlig,1 Stefanie Ranf,1 Marcus Granz,1 Fritz Schwarzmann,1 Hans Wolf,1 and Janos Minarovits2

Institut für Medizinische Mikrobiologie und Hygiene, Universität Regensburg, D-93053 Regensburg, Germany,1 Microbiological Research Group, National Center of Epidemiology, H-1529 Budapest, Hungary2

Received 15 November 2001/ Accepted 15 January 2002

Genomic footprints across Rp, Zp, and oriLyt of Epstein-Barr virus (EBV) have been conducted in a panel of latently infected B-cell lines. Close protein-base contacts were found about 360 nucleotides upstream of the Zp initiation site. Gel shifts and transient transfection assays indicated that an Sp1-NF1 locus may serve as a repressive transcriptional element against Zp induction from latent EBV genomes.

* Corresponding author. Mailing address: Institut für Medizinische Mikrobiologie und Hygiene, Universität Regensburg, Franz-Josef-Strauss-Allee 11, D-93053 Regensburg, Germany. Phone: 49 (941) 944-6451. Fax: 49 (941) 944-6402. E-mail: Hans-Helmut.Niller{at}klinik.uni-regensburg.de.

Journal of Virology, April 2002, p. 4113-4118, Vol. 76, No. 8
0022-538X/02/$04.00+0     DOI: 10.1128/JVI.76.8.4113-4118.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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