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Journal of Virology, April 2002, p. 4108-4112, Vol. 76, No. 8
0022-538X/02/$04.00+0     DOI: 10.1128/JVI.76.8.4108-4112.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Tat-Vaccinated Macaques Do Not Control Simian Immunodeficiency Virus SIVmac239 Replication

Todd M. Allen,1 Lorenzo Mortara,1,{dagger} Bianca R. Mothé,1 Max Liebl,1 Peicheng Jing,1 Briana Calore,1 Marian Piekarczyk,1 Richard Ruddersdorf,1 David H. O'Connor,1 X. Wang,2 Chenxi Wang,3 David B. Allison,3 John D. Altman,2 Alessandro Sette,4 Ronald C. Desrosiers,5 Gerd Sutter,6 and David I. Watkins1,7*

Wisconsin Regional Primate Research Center, University of Wisconsin, Madison, Wisconsin 53715,1 Department of Pathology and Laboratory Medicine, University of Wisconsin Medical School, Madison, Wisconsin 53706,7 Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia 30322,2 Section on Statistical Genetics, Department of Biostatistics and Clinical Nutrition Research Center and Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, Alabama 35294,3 Epimmune Inc., San Diego, California 92121,4 New England Regional Primate Research Center, Southborough, Massachusetts 01772,5 GSF-Institute for Molecular Virology, Munich, Germany 816756

Received 18 October 2001/ Accepted 11 January 2002

The regulatory proteins of human immunodeficiency virus may represent important vaccine targets. Here we assessed the role of Tat-specific cytotoxic T lymphocytes (CTL) in controlling pathogenic simian immunodeficiency virus SIVmac239 replication after using a DNA-prime, vaccinia virus Ankara-boost vaccine regimen. Despite the induction of Tat-specific CTL, there was no significant reduction in either peak or viral set point compared to that of controls.

* Corresponding author. Mailing address: Wisconsin Regional Primate Research Center, University of Wisconsin, 1220 Capitol Ct., Madison, WI 53715. Phone: (608) 265-3380. Fax: (608) 265-8084. E-mail: watkins{at}primate.wisc.edu

{dagger} Present address; Viral Immunology Unit, Advanced Biotechnology Center, 16132 Genoa, Italy.

Journal of Virology, April 2002, p. 4108-4112, Vol. 76, No. 8
0022-538X/02/$04.00+0     DOI: 10.1128/JVI.76.8.4108-4112.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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