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Journal of Virology, April 2002, p. 3579-3584, Vol. 76, No. 7
0022-538X/02/$04.00+0     DOI: 10.1128/JVI.76.7.3579-3584.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Inhibition of In Vitro Leukocyte Proliferation by Morbilliviruses

J. Heaney,1,2 T. Barrett,1 and S. L. Cosby2*

Institute for Animal Health, Pirbright, Surrey GU24 ONF,1 The Queen's University of Belfast, Medical Biology Centre, Belfast BT9 7BL, United Kingdom2

Received 9 August 2001/ Accepted 9 January 2002

Immune suppression associated with morbillivirus infections may influence the mortality rate by allowing secondary bacterial infections that are lethal to the host to flourish. Using an in vitro proliferation assay, we have shown that all members of the genus Morbillivirus inhibit the proliferation of a human B-lymphoblast cell line (BJAB). Proliferation of freshly isolated, stimulated bovine and caprine peripheral blood lymphocytes is also inhibited by UV-inactivated rinderpest (RPV) and peste-des-petits ruminants viruses. As for measles virus, coexpression of both the fusion and the hemagglutinin proteins of RPV is necessary and sufficient to induce immune suppression in vitro.

* Corresponding author. Mailing address: The Queen's University of Belfast, Medical Biology Centre, 97 Lisburn Rd., Belfast BT9 7BL, United Kingdom. Phone: 44(0)28 9027 2127. Fax: 44(0)28 9023 6505. E-mail: l.cosby{at}qub.ac.uk.

Journal of Virology, April 2002, p. 3579-3584, Vol. 76, No. 7
0022-538X/02/$04.00+0     DOI: 10.1128/JVI.76.7.3579-3584.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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