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Journal of Virology, March 2002, p. 3054-3058, Vol. 76, No. 6
0022-538X/02/$04.00+0     DOI: 10.1128/JVI.76.6.3054-3058.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Both R5 and X4 Human Immunodeficiency Virus Type 1 Variants Persist during Prolonged Therapy with Five Antiretroviral Drugs

Ronald P. van Rij,1 Janny A. Visser,1 Rieneke M. E. van Praag,2 Ronald Rientsma,1 Jan M. Prins,2 Joep M. A. Lange,2,3 and Hanneke Schuitemaker1*

Department of Clinical Viro-Immunology, CLB/Sanquin and Landsteiner Laboratory of the Academic Medical Center,1 National AIDS Therapy Evaluation Center, Division of Infectious Diseases, Tropical Medicine and AIDS ,2 Department of Human Retrovirology, Academic Medical Center, University of Amsterdam, 1066 CX Amsterdam, The Netherlands3

Received 1 November 2001/ Accepted 14 December 2001

A viral reservoir of human immunodeficiency virus type 1 (HIV-1)-infected, resting CD4+ T cells persists despite suppression of plasma viremia by combination antiretroviral therapy. In a longitudinal analysis of three patients treated with a five-drug regimen, both R5 and X4 HIV-1 variants persisted in the cellular reservoir for up to 3 years.

* Corresponding author. Mailing address: Department of Clinical Viro-Immunology, CLB Sanquin, Plesmanlaan 125, 1066 CX Amsterdam, The Netherlands. Phone: 31-20-5123317. Fax: 31-20-5123310. E-mail: J_Schuitemaker{at}clb.nl.

Journal of Virology, March 2002, p. 3054-3058, Vol. 76, No. 6
0022-538X/02/$04.00+0     DOI: 10.1128/JVI.76.6.3054-3058.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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