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Journal of Virology, March 2002, p. 3045-3048, Vol. 76, No. 6
0022-538X/02/$04.00+0     DOI: 10.1128/JVI.76.6.3045-3048.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Porcine Endogenous Retrovirus Transmission Characteristics of an Inbred Herd of Miniature Swine

Beth A. Oldmixon,1 James C. Wood,1 Thomas A. Ericsson,1 Carolyn A. Wilson,2 Mary E. White-Scharf,3 Goran Andersson,3 Julia L. Greenstein,1 Henk-Jan Schuurman,1 and Clive Patience1,3*

Immerge BioTherapeutics, Inc.,1 BioTransplant, Inc., Charlestown, Massachusetts,3 Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Federal Drug Administration, Bethesda, Maryland2

Received 1 October 2001/ Accepted 19 December 2001

Here we report the identification of inbred miniature swine that failed to produce human-tropic replication-competent porcine endogenous retroviruses (HTRC PERVs), using in vitro coculture assays. When HTRC PERVs were isolated from transmitting animals, all were recombinant viruses, with the receptor-binding domain of PERV-A combining with PERV-C-related sequences.

* Corresponding author. Mailing address: Immerge BioTherapeutics, Inc., Building 75, 3rd Ave., Charlestown, MA 02129. Phone: (617) 241-5565. Fax: (617) 241-0539. E-mail: clive.patience{at}immergebt.com.

Journal of Virology, March 2002, p. 3045-3048, Vol. 76, No. 6
0022-538X/02/$04.00+0     DOI: 10.1128/JVI.76.6.3045-3048.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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