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Journal of Virology, March 2002, p. 3045-3048, Vol. 76, No. 6
0022-538X/02/$04.00+0     DOI: 10.1128/JVI.76.6.3045-3048.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Porcine Endogenous Retrovirus Transmission Characteristics of an Inbred Herd of Miniature Swine

Immerge BioTherapeutics, Inc.,¹ BioTransplant, Inc., Charlestown, Massachusetts,³ Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Federal Drug Administration, Bethesda, Maryland²

Received 1 October 2001/ Accepted 19 December 2001

Here we report the identification of inbred miniature swine that failed to produce human-tropic replication-competent porcine endogenous retroviruses (HTRC PERVs), using in vitro coculture assays. When HTRC PERVs were isolated from transmitting animals, all were recombinant viruses, with the receptor-binding domain of PERV-A combining with PERV-C-related sequences.

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