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Journal of Virology, March 2002, p. 2567-2572, Vol. 76, No. 5
0022-538X/02/$04.00+0     DOI: 10.1128/jvi.76.5.2567-2572.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Sequence Variation in a Newly Identified HLA-B35-Restricted Epitope in the Influenza A Virus Nucleoprotein Associated with Escape from Cytotoxic T Lymphocytes

*** A. C. M. Boon,1 G. de Mutsert,1 Y. M. F. Graus,2 R. A. M. Fouchier,1 K. Sintnicolaas,3 A. D. M. E. Osterhaus,1 and G. F. Rimmelzwaan1*

Institute of Virology, Erasmus University Rotterdam, 3015 GE Rotterdam,1 Numico Research B. V., 6700 CA Wageningen,2 Laboratory for Histocompatibility and Immunogenetics, Bloodbank Rotterdam, 3318 AS Dordrecht, The Netherlands3

Received 24 September 2001/ Accepted 28 November 2001

Here, we describe a new HLA-B*3501-restricted cytotoxic T lymphocyte (CTL) epitope in the influenza A virus (H3N2) nucleoprotein, which was found to exhibit a high degree of variation at nonanchor residues. The influenza virus variants emerged in chronological order, and CTLs directed against old variants failed to recognize more recent strains of influenza A virus, indicating an escape from CTL immunity.

* Corresponding author. Mailing address: Institute of Virology, Erasmus University Rotterdam, Dr. Molewaterplein 50, 3015 GE Rotterdam, The Netherlands. Phone: 31-10-4088066. Fax: 31-10-4089485. E-mail: rimmelzwaan{at}viro.fgg.eur.nl.

Journal of Virology, March 2002, p. 2567-2572, Vol. 76, No. 5
0022-538X/02/$04.00+0     DOI: 10.1128/jvi.76.5.2567-2572.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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