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Journal of Virology, March 2002, p. 2551-2556, Vol. 76, No. 5
0022-538X/02/$04.00+0     DOI: 10.1128/jvi.76.5.2551-2556.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Differential Expression of Viral Bcl-2 Encoded by Kaposi's Sarcoma-Associated Herpesvirus and Human Bcl-2 in Primary Effusion Lymphoma Cells and Kaposi's Sarcoma Lesions

*** Isabelle Widmer,1 Marion Wernli,1 Felix Bachmann,1 Fred Gudat,2 Gieri Cathomas,3 and Peter Erb1*

Institute for Medical Microbiology, University of Basel,1 Institute for Pathology, CH-4003 Basel,2 Institute for Pathology, CH-4410 Liestal, Switzerland3

Received 23 April 2001/ Accepted 5 December 2001

Expression of human herpesvirus 8 viral Bcl-2 protein was demonstrated in spindle cells of late-stage Kaposi's sarcoma lesions but not in primary effusion lymphoma cell lines. In contrast, strong expression of human Bcl-2 was found in stimulated primary effusion lymphoma cells, whereas in Kaposi's sarcoma lesions preferential mononuclear cells, and to a lesser extent spindle cells, stained positive.

* Corresponding author. Mailing address: Institute for Medical Microbiology, University of Basel, Petersplatz 10, CH-4003 Basel, Switzerland. Phone: 4161 267 32 75. Fax: 4161 267 32 98. E-mail: peter.erb{at}unibas.ch.

Journal of Virology, March 2002, p. 2551-2556, Vol. 76, No. 5
0022-538X/02/$04.00+0     DOI: 10.1128/jvi.76.5.2551-2556.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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