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Journal of Virology, February 2002, p. 2024-2027, Vol. 76, No. 4
0022-538X/01/$04.00+0     DOI: 10.1128/JVI.76.4.2024-2027.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

A Novel Expression Cassette of Lyssavirus Shows that the Distantly Related Mokola Virus Can Rescue a Defective Rabies Virus Genome

Philippe Le Mercier,1* Yves Jacob,1 Kyle Tanner,2 and Noël Tordo1

Laboratoire des Lyssavirus, Institut Pasteur, 75724 Paris Cédex 15, France,1 Département de Biochimie Médicale, Centre Médical Universitaire, CH1211 Geneva, Switzerland2

Received 9 April 2001/ Accepted 26 September 2001

By comparing three expression vectors for the rabies virus (Rv) minigenome, we show that the characteristic of the Rv RNA is important for efficient rescue despite its not being crucial for replication. Moreover, we show that the coexpression of the viral proteins from helper Rv and Mokola virus could rescue the Rv minigenome while Rv-related European bat lyssavirus 1 could not, suggesting that the signals controlling transcription and replication are conserved in the distantly related Rv and Mokola virus.

* Corresponding author. Mailing address: Department of Genetics and Microbiology, University of Geneva School of Medicine, CMU, 9 Ave. de Champel, CH1211 Geneva, Switzerland. Phone: (41 22) 702-5676. Fax: (41 22) 702-5702. E-mail: Philippe.LeMercier{at}medecine.unige.ch.

Journal of Virology, February 2002, p. 2024-2027, Vol. 76, No. 4
0022-538X/01/$04.00+0     DOI: 10.1128/JVI.76.4.2024-2027.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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