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Journal of Virology, February 2002, p. 1986-1990, Vol. 76, No. 4
0022-538X/01/$04.00+0     DOI: 10.1128/JVI.76.4.1986-1990.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Inhibition of Duck Hepatitis B Virus Infection by a Myristoylated Pre-S Peptide of the Large Viral Surface Protein

Stephan Urban1* and Philippe Gripon2

Zentrum für Molekulare Biologie, Universität Heidelberg (ZMBH), 69120 Heidelberg, Germany,1 Régulation des Equilibres Fonctionnels du Foie Normal et Pathologique U 522, Institut National de la Santé et de la Recherche Médicale, Hôpital de Pontchaillou, 35033 Rennes Cedex, France2

Received 15 October 2001/ Accepted 7 November 2001

We have used the duck hepatitis B virus (DHBV) model to study the interference with infection by a myristoylated peptide representing an N-terminal pre-S subdomain of the large viral envelope protein. Although lacking the essential part of the carboxypeptidase D (formerly called gp180) receptor binding site, the peptide binds hepatocytes and subsequently blocks DHBV infection. Since its activity requires an amino acid sequence involved in host discrimination between DHBV and the related heron HBV (T. Ishikawa and D. Ganem, Proc. Natl. Acad. Sci. USA 92:6259-6263, 1995), we suggest that it is related to the postulated host-discriminating cofactor of infection.

* Corresponding author. Present address: Otto-Meyerhof-Zentrum (OMZ), University of Heidelberg, Internal Medicine IV, Im Neuenheimer Feld 350, 69120 Heidelberg, Germany. Phone: 49-6221-562910. Fax: 49-6221-561946. E-mail: s.urban{at}med.uni-heidelberg.de.

Journal of Virology, February 2002, p. 1986-1990, Vol. 76, No. 4
0022-538X/01/$04.00+0     DOI: 10.1128/JVI.76.4.1986-1990.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Gudima, S., Meier, A., Dunbrack, R., Taylor, J., Bruss, V. (2007). Two Potentially Important Elements of the Hepatitis B Virus Large Envelope Protein Are Dispensable for the Infectivity of Hepatitis Delta Virus. J. Virol. 81: 4343-4347 [Abstract] [Full Text]  
  • Barrera, A., Guerra, B., Notvall, L., Lanford, R. E. (2005). Mapping of the Hepatitis B Virus Pre-S1 Domain Involved in Receptor Recognition. J. Virol. 79: 9786-9798 [Abstract] [Full Text]  
  • Lin, L., Prassolov, A., Funk, A., Quinn, L., Hohenberg, H., Frolich, K., Newbold, J., Ludwig, A., Will, H., Sirma, H., Steinbach, F. (2005). Evidence from nature: interspecies spread of heron hepatitis B viruses. J. Gen. Virol. 86: 1335-1342 [Abstract] [Full Text]  
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