This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Takemura, T.
Right arrow Articles by Hayami, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Takemura, T.
Right arrow Articles by Hayami, M.

 Previous Article  |  Next Article 

Journal of Virology, February 2002, p. 1642-1648, Vol. 76, No. 4
0022-538X/01/$04.00+0     DOI: 10.1128/JVI.76.4.1642-1648.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

High Prevalence of Simian T-Lymphotropic Virus Type L in Wild Ethiopian Baboons

Taichiro Takemura,1 Masahiro Yamashita,1* Makoto K. Shimada,2,{dagger} Sadayuki Ohkura,1 Takayoshi Shotake,2 Mikio Ikeda,3 Tomoyuki Miura,1 and Masanori Hayami1

Institute for Virus Research, Kyoto University, Kyoto 606-8507,1 Primate Research Institute, Kyoto University, Inuyama 484-8506,,2 Fujirebio Inc., Tokyo 103-0007, Japan3

Received 10 September 2001/ Accepted 13 November 2001

Simian T-cell leukemia viruses (STLVs) are the simian counterparts of human T-cell leukemia viruses (HTLVs). A novel, divergent type of STLV (STLV-L) from captive baboons was reported in 1994, but its natural prevalence remained unclear. We investigated the prevalence of STLV-L in 519 blood samples from wild-living nonhuman primates in Ethiopia. Seropositive monkeys having cross-reactive antibodies against HTLV were found among 22 out of 40 hamadryas baboons, 8 of 96 anubis baboons, 24 of 50 baboons that are hybrids between hamadryas and anubis baboons, and 41 of 177 grivet monkeys, but not in 156 gelada baboons. A Western blotting assay showed that sera obtained from seropositive hamadryas and hybrid baboons exhibited STLV-L-like reactivity. A PCR assay successfully amplified STLV sequences, which were subsequently sequenced and confirmed as being closely related to STLV-L. Surprisingly, further PCR showed that nearly half of the hamadryas (20 out of 40) and hybrid (19 out of 50) baboons had STLV-L DNA sequences. In contrast, most of the seropositive anubis baboons and grivet monkeys carried typical STLV-1 but not STLV-L. These observations demonstrate that STLV-L naturally prevails among hamadryas and hybrid baboons at significantly high rates. STLV-1 and -2, the close relative of STLV-L, are believed to have jumped across simian-human barriers, which resulted in widespread infection of HTLV-1 and -2. Further studies are required to know if STLV-L is spreading into human populations.

* Corresponding author. Present address: Division of Human Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N., Seattle, WA 98109-1024. Phone: (206) 667-5754. Fax: (206) 667-6523. E-mail: myamashi{at}fhcrc.org.

{dagger} Present address: National Institute of Genetics, Mishima 411-8540, Japan.

Journal of Virology, February 2002, p. 1642-1648, Vol. 76, No. 4
0022-538X/01/$04.00+0     DOI: 10.1128/JVI.76.4.1642-1648.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Chevalier, S. A., Ko, N. L., Calattini, S., Mallet, A., Prevost, M.-C., Kehn, K., Brady, J. N., Kashanchi, F., Gessain, A., Mahieux, R. (2008). Construction and Characterization of a Human T-Cell Lymphotropic Virus Type 3 Infectious Molecular Clone. J. Virol. 82: 6747-6752 [Abstract] [Full Text]  
  • Chevalier, S. A., Walic, M., Calattini, S., Mallet, A., Prevost, M.-C., Gessain, A., Mahieux, R. (2007). Construction and Characterization of a Full-Length Infectious Simian T-Cell Lymphotropic Virus Type 3 Molecular Clone. J. Virol. 81: 6276-6285 [Abstract] [Full Text]  
  • Switzer, W. M., Qari, S. H., Wolfe, N. D., Burke, D. S., Folks, T. M., Heneine, W. (2006). Ancient origin and molecular features of the novel human T-lymphotropic virus type 3 revealed by complete genome analysis.. J. Virol. 80: 7427-7438 [Abstract] [Full Text]  
  • Courgnaud, V., Van Dooren, S., Liegeois, F., Pourrut, X., Abela, B., Loul, S., Mpoudi-Ngole, E., Vandamme, A., Delaporte, E., Peeters, M. (2004). Simian T-Cell Leukemia Virus (STLV) Infection in Wild Primate Populations in Cameroon: Evidence for Dual STLV Type 1 and Type 3 Infection in Agile Mangabeys (Cercocebus agilis). J. Virol. 78: 4700-4709 [Abstract] [Full Text]  
  • Van Dooren, S., Shanmugam, V., Bhullar, V., Parekh, B., Vandamme, A.-M., Heneine, W., Switzer, W. M. (2004). Identification in gelada baboons (Theropithecus gelada) of a distinct simian T-cell lymphotropic virus type 3 with a broad range of Western blot reactivity. J. Gen. Virol. 85: 507-519 [Abstract] [Full Text]  
  • Meertens, L., Shanmugam, V., Gessain, A., Beer, B. E., Tooze, Z., Heneine, W., Switzer, W. M. (2003). A novel, divergent simian T-cell lymphotropic virus type 3 in a wild-caught red-capped mangabey (Cercocebus torquatus torquatus) from Nigeria. J. Gen. Virol. 84: 2723-2727 [Abstract] [Full Text]  
  • Niphuis, H., Verschoor, E. J., Bontjer, I., Peeters, M., Heeney, J. L. (2003). Reduced transmission and prevalence of simian T-cell lymphotropic virus in a closed breeding colony of chimpanzees (Pan troglodytes verus). J. Gen. Virol. 84: 615-620 [Abstract] [Full Text]  
  • Meertens, L., Gessain, A. (2002). Divergent Simian T-Cell Lymphotropic Virus Type 3 (STLV-3) in Wild-Caught Papio hamadryas papio from Senegal: Widespread Distribution of STLV-3 in Africa. J. Virol. 77: 782-789 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»