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 Previous Article

Journal of Virology, February 2002, p. 1533-1536, Vol. 76, No. 3
0022-538X/01/$04.00+0     DOI: 10.1128/JVI.76.3.1533-1536.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Increased p50/p50 NF-{kappa}B Activation in Human Papillomavirus Type 6- or Type 11-Induced Laryngeal Papilloma Tissue

Ivana Vancurova,1 Rong Wu,2 Veronika Miskolci,1 and Shishinn Sun2*

Department of Pediatrics,1 Department of Otolaryngology, Long Island Jewish Medical Center, New Hyde Park, New York2

Received 18 July 2001/ Accepted 26 October 2001

We have observed elevated NF-{kappa}B DNA-binding activity in nuclear extracts from human papillomavirus type 6- and 11-infected laryngeal papilloma tissues. The predominant DNA-binding species is the p50/p50 homodimer. The elevated NF-{kappa}B activity could be correlated with a reduced level of cytoplasmic I{kappa}Bß and could be associated with the overexpression of p21CIP1/WAF1 in papilloma cells. Increased NF-{kappa}B activity and cytoplasmic accumulation of p21CIP1/WAF1 might counteract death-promoting effects elicited by overexpressed PTEN and reduced activation of Akt and STAT3 previously noted in these tissues.

* Corresponding author. Mailing address: Department of Otolaryngology, Long Island Jewish Medical Center, 270-05 76th Ave., New Hyde Park, NY 11040. Phone: (718) 470-7576. Fax: (718) 347-2320. E-mail: sun{at}lij.edu.

Journal of Virology, February 2002, p. 1533-1536, Vol. 76, No. 3
0022-538X/01/$04.00+0     DOI: 10.1128/JVI.76.3.1533-1536.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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