This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Vancurova, I. Articles by Sun, S. Search for Related Content PubMed PubMed Citation Articles by Vancurova, I. Articles by Sun, S.

 Previous Article

Journal of Virology, February 2002, p. 1533-1536, Vol. 76, No. 3
0022-538X/01/$04.00+0     DOI: 10.1128/JVI.76.3.1533-1536.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Increased p50/p50 NF-B Activation in Human Papillomavirus Type 6- or Type 11-Induced Laryngeal Papilloma Tissue

Department of Pediatrics,¹ Department of Otolaryngology, Long Island Jewish Medical Center, New Hyde Park, New York²

Received 18 July 2001/ Accepted 26 October 2001

We have observed elevated NF-B DNA-binding activity in nuclear extracts from human papillomavirus type 6- and 11-infected laryngeal papilloma tissues. The predominant DNA-binding species is the p50/p50 homodimer. The elevated NF-B activity could be correlated with a reduced level of cytoplasmic IBß and could be associated with the overexpression of p21^CIP1/WAF1 in papilloma cells. Increased NF-B activity and cytoplasmic accumulation of p21^CIP1/WAF1 might counteract death-promoting effects elicited by overexpressed PTEN and reduced activation of Akt and STAT3 previously noted in these tissues.

This article has been cited by other articles:

• Wu, R., Abramson, A. L., Shikowitz, M. J., Dannenberg, A. J., Steinberg, B. M. (2005). Epidermal Growth Factor-Induced Cyclooxygenase-2 Expression Is Mediated through Phosphatidylinositol-3 Kinase, Not Mitogen-Activated Protein/Extracellular Signal-Regulated Kinase Kinase, in Recurrent Respiratory Papillomas. Clin. Cancer Res. 11: 6155-6161 [Abstract] [Full Text]  
• Bai, Y., Onuma, H., Bai, X., Medvedev, A. V., Misukonis, M., Weinberg, J. B., Cao, W., Robidoux, J., Floering, L. M., Daniel, K. W., Collins, S. (2005). Persistent Nuclear Factor-{kappa}B Activation in Ucp2-/- Mice Leads to Enhanced Nitric Oxide and Inflammatory Cytokine Production. J. Biol. Chem. 280: 19062-19069 [Abstract] [Full Text]  
• Thornburg, N. J., Pathmanathan, R., Raab-Traub, N. (2003). Activation of Nuclear Factor-{kappa}B p50 Homodimer/Bcl-3 Complexes in Nasopharyngeal Carcinoma. Cancer Res. 63: 8293-8301 [Abstract] [Full Text]  
• Lin, L., Kobayashi, M. (2003). Stability of the Rel Homology Domain Is Critical for Generation of NF-{kappa}B p50 Subunit. J. Biol. Chem. 278: 31479-31485 [Abstract] [Full Text]  
• Du, J., Chen, G. G., Vlantis, A. C., Xu, H., Tsang, R. K.Y., van Hasselt, A. C. (2003). The Nuclear Localization of NF{kappa}B and p53 Is Positively Correlated with HPV16 E7 Level in Laryngeal Squamous Cell Carcinoma. J. Histochem. Cytochem. 51: 533-539 [Abstract] [Full Text]  
• Castro-Alcaraz, S., Miskolci, V., Kalasapudi, B., Davidson, D., Vancurova, I. (2002). NF-{kappa}B Regulation in Human Neutrophils by Nuclear I{kappa}B{alpha}: Correlation to Apoptosis. J. Immunol. 169: 3947-3953 [Abstract] [Full Text]  
• Spitkovsky, D., Hehner, S. P., Hofmann, T. G., Moller, A., Schmitz, M. L. (2002). The Human Papillomavirus Oncoprotein E7 Attenuates NF-kappa B Activation by Targeting the Ikappa B Kinase Complex. J. Biol. Chem. 277: 25576-25582 [Abstract] [Full Text]  
• Sun, S., Steinberg, B. M. (2002). PTEN is a negative regulator of STAT3 activation in human papillomavirus-infected cells. J. Gen. Virol. 83: 1651-1658 [Abstract] [Full Text]