This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Scripture-Adams, D. D. Articles by Zack, J. A. Search for Related Content PubMed PubMed Citation Articles by Scripture-Adams, D. D. Articles by Zack, J. A.

 Previous Article  |  Next Article 

Journal of Virology, December 2002, p. 13077-13082, Vol. 76, No. 24
0022-538X/02/$04.00+0     DOI: 10.1128/JVI.76.24.13077-13082.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Interleukin-7 Induces Expression of Latent Human Immunodeficiency Virus Type 1 with Minimal Effects on T-Cell Phenotype

Department of Microbiology, Immunology, and Molecular Genetics,¹ Department of Medicine and AIDS Institute, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095²

Received 12 June 2002/ Accepted 16 September 2002

Latent human immunodeficiency virus type 1 (HIV-1) persists even in patients treated with antiretroviral therapy. New treatment strategies are therefore needed to eradicate this latent viral reservoir without reducing immune cell function. We characterize the interleukin-7 (IL-7)-induced stimulation of primary human T cells and thymocytes and demonstrate, using the SCID-hu model, that IL-7 induces substantial expression of latent HIV while having minimal effects on the cell phenotype. Thus, IL-7 is a viable candidate to activate expression of latent HIV and may facilitate immune clearance of latently infected cells.

This article has been cited by other articles:

• Burke, B., Brown, H. J., Marsden, M. D., Bristol, G., Vatakis, D. N., Zack, J. A. (2007). Primary Cell Model for Activation-Inducible Human Immunodeficiency Virus. J. Virol. 81: 7424-7434 [Abstract] [Full Text]  
• Hryniewicz, A., Price, D. A., Moniuszko, M., Boasso, A., Edghill-Spano, Y., West, S. M., Venzon, D., Vaccari, M., Tsai, W.-P., Tryniszewska, E., Nacsa, J., Villinger, F., Ansari, A. A., Trindade, C. J., Morre, M., Brooks, D., Arlen, P., Brown, H. J., Kitchen, C. M. R., Zack, J. A., Douek, D. C., Shearer, G. M., Lewis, M. G., Koup, R. A., Franchini, G. (2007). Interleukin-15 but Not Interleukin-7 Abrogates Vaccine-Induced Decrease in Virus Level in Simian Immunodeficiency Virusmac251-Infected Macaques. J. Immunol. 178: 3492-3504 [Abstract] [Full Text]  
• Albuquerque, A. S., Cortesao, C. S., Foxall, R. B., Soares, R. S., Victorino, R. M. M., Sousa, A. E. (2007). Rate of Increase in Circulating IL-7 and Loss of IL-7R{alpha} Expression Differ in HIV-1 and HIV-2 Infections: Two Lymphopenic Diseases with Similar Hyperimmune Activation but Distinct Outcomes. J. Immunol. 178: 3252-3259 [Abstract] [Full Text]  
• Shen, A., Yang, H.-C., Zhou, Y., Chase, A. J., Boyer, J. D., Zhang, H., Margolick, J. B., Zink, M. C., Clements, J. E., Siliciano, R. F. (2007). Novel Pathway for Induction of Latent Virus from Resting CD4+ T Cells in the Simian Immunodeficiency Virus/Macaque Model of Human Immunodeficiency Virus Type 1 Latency. J. Virol. 81: 1660-1670 [Abstract] [Full Text]  
• Bailey, J. R., Sedaghat, A. R., Kieffer, T., Brennan, T., Lee, P. K., Wind-Rotolo, M., Haggerty, C. M., Kamireddi, A. R., Liu, Y., Lee, J., Persaud, D., Gallant, J. E., Cofrancesco, J. Jr., Quinn, T. C., Wilke, C. O., Ray, S. C., Siliciano, J. D., Nettles, R. E., Siliciano, R. F. (2006). Residual Human Immunodeficiency Virus Type 1 Viremia in Some Patients on Antiretroviral Therapy Is Dominated by a Small Number of Invariant Clones Rarely Found in Circulating CD4+ T Cells.. J. Virol. 80: 6441-6457 [Abstract] [Full Text]  
• Zhang, M., Drenkow, J., Lankford, C. S. R., Frucht, D. M., Rabin, R. L., Gingeras, T. R., Venkateshan, C., Schwartzkopff, F., Clouse, K. A., Dayton, A. I. (2006). HIV regulation of the IL-7R: a viral mechanism for enhancing HIV-1 replication in human macrophages in vitro. J. Leukoc. Biol. 79: 1328-1338 [Abstract] [Full Text]  
• Swainson, L., Verhoeyen, E., Cosset, F.-L., Taylor, N. (2006). IL-7R{alpha} Gene Expression Is Inversely Correlated with Cell Cycle Progression in IL-7-Stimulated T Lymphocytes.. J. Immunol. 176: 6702-6708 [Abstract] [Full Text]  
• Resino, S., Perez, A., Leon, J. A., Gurbindo, M. D., Munoz-Fernandez, M. A. (2006). Interleukin-7 levels before highly active antiretroviral therapy may predict CD4+ T-cell recovery and virological failure in HIV-infected children. J Antimicrob Chemother 57: 798-800 [Full Text]  
• Gondois-Rey, F., Biancotto, A., Fernandez, M. A., Bettendroffer, L., Blazkova, J., Trejbalova, K., Pion, M., Hirsch, I. (2006). R5 Variants of Human Immunodeficiency Virus Type 1 Preferentially Infect CD62L- CD4+ T Cells and Are Potentially Resistant to Nucleoside Reverse Transcriptase Inhibitors. J. Virol. 80: 854-865 [Abstract] [Full Text]  
• Beq, S., Nugeyre, M.-T., Fang, R. H. T., Gautier, D., Legrand, R., Schmitt, N., Estaquier, J., Barre-Sinoussi, F., Hurtrel, B., Cheynier, R., Israel, N. (2006). IL-7 Induces Immunological Improvement in SIV-Infected Rhesus Macaques under Antiviral Therapy. J. Immunol. 176: 914-922 [Abstract] [Full Text]  
• Muthukumar, A., Zhou, D., Paiardini, M., Barry, A. P., Cole, K. S., McClure, H. M., Staprans, S. I., Silvestri, G., Sodora, D. L. (2005). Timely triggering of homeostatic mechanisms involved in the regulation of T-cell levels in SIVsm-infected sooty mangabeys. Blood 106: 3839-3845 [Abstract] [Full Text]  
• Audige, A., Schlaepfer, E., Joller, H., Speck, R. F. (2005). Uncoupled Anti-HIV and Immune-Enhancing Effects when Combining IFN-{alpha} and IL-7. J. Immunol. 175: 3724-3736 [Abstract] [Full Text]  
• Choi, J., Walker, J., Talbert-Slagle, K., Wright, P., Pober, J. S., Alexander, L. (2005). Endothelial Cells Promote Human Immunodeficiency Virus Replication in Nondividing Memory T Cells via Nef-, Vpr-, and T-Cell Receptor-Dependent Activation of NFAT. J. Virol. 79: 11194-11204 [Abstract] [Full Text]  
• Trushin, S. A., Bren, G. D., Asin, S., Pennington, K. N., Paya, C. V., Badley, A. D. (2005). Human Immunodeficiency Virus Reactivation by Phorbol Esters or T-Cell Receptor Ligation Requires both PKC{alpha} and PKC{theta}. J. Virol. 79: 9821-9830 [Abstract] [Full Text]  
• Lassen, K. G., Bailey, J. R., Siliciano, R. F. (2004). Analysis of Human Immunodeficiency Virus Type 1 Transcriptional Elongation in Resting CD4+ T Cells In Vivo. J. Virol. 78: 9105-9114 [Abstract] [Full Text]  
• Han, Y., Lassen, K., Monie, D., Sedaghat, A. R., Shimoji, S., Liu, X., Pierson, T. C., Margolick, J. B., Siliciano, R. F., Siliciano, J. D. (2004). Resting CD4+ T Cells from Human Immunodeficiency Virus Type 1 (HIV-1)-Infected Individuals Carry Integrated HIV-1 Genomes within Actively Transcribed Host Genes. J. Virol. 78: 6122-6133 [Abstract] [Full Text]  
• Saavedra-Lozano, J., Cao, Y., Callison, J., Sarode, R., Sodora, D., Edgar, J., Hatfield, J., Picker, L., Peterson, D., Ramilo, O., Vitetta, E. S. (2004). An anti-CD45RO immunotoxin kills HIV-latently infected cells from individuals on HAART with little effect on CD8 memory. Proc. Natl. Acad. Sci. USA 101: 2494-2499 [Abstract] [Full Text]  
• Muthukumar, A., Wozniakowski, A., Gauduin, M.-C., Paiardini, M., McClure, H. M., Johnson, R. P., Silvestri, G., Sodora, D. L. (2004). Elevated interleukin-7 levels not sufficient to maintain T-cell homeostasis during simian immunodeficiency virus-induced disease progression. Blood 103: 973-979 [Abstract] [Full Text]  
• Brooks, D. G., Arlen, P. A., Gao, L., Kitchen, C. M. R., Zack, J. A. (2003). Identification of T cell-signaling pathways that stimulate latent HIV in primary cells. Proc. Natl. Acad. Sci. USA 100: 12955-12960 [Abstract] [Full Text]  
• Nugeyre, M.-T., Monceaux, V., Beq, S., Cumont, M.-C., Fang, R. H. T., Chene, L., Morre, M., Barre-Sinoussi, F., Hurtrel, B., Israel, N. (2003). IL-7 Stimulates T Cell Renewal Without Increasing Viral Replication in Simian Immunodeficiency Virus-Infected Macaques. J. Immunol. 171: 4447-4453 [Abstract] [Full Text]