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Journal of Virology, December 2002, p. 12394-12398, Vol. 76, No. 23
0022-538X/02/$04.00+0     DOI: 10.1128/JVI.76.23.12394-12398.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Involvement of Apolipoprotein E in the Hematogenous Route of Herpes Simplex Virus Type 1 to the Central Nervous System

Javier S. Burgos, Carlos Ramirez, Isabel Sastre, María J. Bullido, and Fernando Valdivieso*

Departamento de Biología Molecular and Centro de Biología Molecular Severo Ochoa (C.S.I.C.-U.A.M.), Universidad Autónoma de Madrid, Cantoblanco, 28049 Madrid, Spain

Received 15 August 2002/ Accepted 26 August 2002

Apolipoprotein E (ApoE), a constituent of the lipoproteins, may be relevant in herpes simplex virus type 1 (HSV-1) infection of the central nervous system (CNS), since HSV-1 binds to human serum ApoE lipoproteins. This study demonstrates the involvement of ApoE in the hematogenous route of HSV-1 to the CNS.

* Corresponding author. Mailing address: Departamento de Biología Molecular and Centro de Biología Molecular Severo Ochoa (C.S.I.C.-U.A.M.), Universidad Autónoma de Madrid, Cantoblanco, 28049 Madrid, Spain. Phone: 34 91 3978471. Fax: 34 91 3974870. E-mail: fvaldivieso{at}cbm.uam.es.

Journal of Virology, December 2002, p. 12394-12398, Vol. 76, No. 23
0022-538X/02/$04.00+0     DOI: 10.1128/JVI.76.23.12394-12398.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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