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Journal of Virology, December 2002, p. 12369-12375, Vol. 76, No. 23
0022-538X/02/$04.00+0     DOI: 10.1128/JVI.76.23.12369-12375.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Host Range and Receptor Binding Properties of Vectors Bearing Feline Leukemia Virus Subgroup B Envelopes Can Be Modulated by Envelope Sequences outside of the Receptor Binding Domain

Peggy Ho Faix,1 Steven A. Feldman,1 Julie Overbaugh,2 and Maribeth V. Eiden1*

Laboratory of Cellular and Molecular Regulation, National Institute of Mental Health, Bethesda, Maryland,1 Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington2

Received 23 May 2002/ Accepted 22 August 2002

To evaluate host range differences between two different strains of feline leukemia virus subgroup B (FeLV-B), we compared the binding and infectivity patterns of retrovirus vectors bearing either FeLV-B-90Z or FeLV-B-GA envelopes. We report here that the ability of these envelopes to utilize different Pit1 orthologs is mediated primarily by the receptor binding domain; however, in the case of FeLV-B-90Z, the C terminus also contributes to the recognition of certain Pit1 orthologs.

* Corresponding author. Mailing address: Building 36, Room 2A11, Section on Molecular Virology, Laboratory of Cellular and Molecular Regulation, National Institute of Mental Health, 36 Convent Dr., MSC 4068, Bethesda, MD 20892. Phone: (301) 402-1641. Fax: (301) 402-5358. E-mail: m_eiden{at}codon.nih.gov.

Journal of Virology, December 2002, p. 12369-12375, Vol. 76, No. 23
0022-538X/02/$04.00+0     DOI: 10.1128/JVI.76.23.12369-12375.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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