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Journal of Virology, December 2002, p. 12365-12368, Vol. 76, No. 23
0022-538X/02/$04.00+0     DOI: 10.1128/JVI.76.23.12365-12368.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Comparison of Abnormal Prion Protein Glycoform Patterns from Transmissible Spongiform Encephalopathy Agent-Infected Deer, Elk, Sheep, and Cattle

Richard E. Race,1* Anne Raines,1 Thierry G. M. Baron,2 Michael W. Miller,3 Allen Jenny,4 and Elizabeth S. Williams5

Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, Montana,1 Agence Francaise de Securite Sanitaire des Aliments, Lyon, France,2 Wildlife Research Center, Colorado Division of Wildlife, Fort Collins, Colorado,3 Veterinary Services Laboratories, Animal and Plant Health Inspection Service, U.S. Department of Agriculture, Ames, Iowa,4 Department of Veterinary Sciences, University of Wyoming, Laramie, Wyoming5

Received 29 April 2002/ Accepted 23 August 2002

Analysis of abnormal prion protein glycoform patterns from chronic wasting disease (CWD)-affected deer and elk, scrapie-affected sheep and cattle, and cattle with bovine spongiform encephalopathy failed to identify patterns capable of reliably distinguishing these transmissible spongiform encephalopathy diseases. However, PrP-res patterns sometimes differed among individual animals, suggesting infection by different or multiple CWD strains in some species.

* Corresponding author. Mailing address: Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, 903 S. Fourth St., Hamilton, MT 59840. Phone: (406) 363-9358. Fax: (406) 363-9286. E-mail: rrace{at}niaid.nih.gov.

Journal of Virology, December 2002, p. 12365-12368, Vol. 76, No. 23
0022-538X/02/$04.00+0     DOI: 10.1128/JVI.76.23.12365-12368.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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