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Journal of Virology, December 2002, p. 12344-12348, Vol. 76, No. 23
0022-538X/02/$04.00+0     DOI: 10.1128/JVI.76.23.12344-12348.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Viral Evolution during Structured Treatment Interruptions in Chronically Human Immunodeficiency Virus-Infected Individuals

Javier Martinez-Picado,1* Simon D. W. Frost,2 Nuria Izquierdo,1 K. Morales-Lopetegi,1 Silvia Marfil,1 Teresa Puig,1 Cecilia Cabrera,1 Bonaventura Clotet,1 and Lidia Ruiz1

IrsiCaixa Foundation, Hospital Germans Trias i Pujol, Universitat Autonoma de Barcelona, Badalona, Spain,1 University of California at San Diego Antiviral Research Center, San Diego, California2

Received 10 April 2002/ Accepted 22 August 2002

We analyzed the evolution of the human immunodeficiency virus type 1 (HIV-1) env gene in 12 chronically infected individuals who underwent structured treatment interruptions (STIs). Analyses of length variation and of clonal sequences demonstrated highly unpredictable evolution, which may limit the strengthening of HIV-specific immune responses by STIs because of the variability in exposure to viral antigens.

* Corresponding author. Mailing address: IrsiCaixa Foundation, Hospital Germans Trias i Pujol, Ctra. de Canyet s/n, 08916 Badalona, Spain. Phone: 34 93 4656374. Fax: 34 93 4653968. E-mail: javiermp{at}ns.hugtip.scs.es.

Journal of Virology, December 2002, p. 12344-12348, Vol. 76, No. 23
0022-538X/02/$04.00+0     DOI: 10.1128/JVI.76.23.12344-12348.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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