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Journal of Virology, December 2002, p. 12335-12343, Vol. 76, No. 23
0022-538X/02/$04.00+0     DOI: 10.1128/JVI.76.23.12335-12343.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Binding of Norwalk Virus-Like Particles to ABH Histo-Blood Group Antigens Is Blocked by Antisera from Infected Human Volunteers or Experimentally Vaccinated Mice

Patrick R. Harrington,1 Lisa Lindesmith,2 Boyd Yount,2 Christine L. Moe,3 and Ralph S. Baric1,2*

Department of Microbiology and Immunology, School of Medicine,1 Program in Infectious Diseases, Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7435,2 Department of International Health, Rollins School of Public Health, Emory University, Atlanta, Georgia 303223

Received 16 July 2002/ Accepted 26 August 2002

Attachment of Norwalk (NV), Snow Mountain (SMV), and Hawaii (HV) virus-like particles (VLPs) to specific ABH histo-blood group antigens was investigated by using human saliva and synthetic biotinylated carbohydrates. The three distinct Norwalk-like viruses (NLVs) have various capacities for binding ABH histo-blood group antigens, suggesting that different mechanisms for NLV attachment likely exist. Importantly, antisera from NV-infected human volunteers, as well as from mice inoculated with packaged Venezuelan equine encephalitis virus replicons expressing NV VLPs, blocked the ability of NV VLPs to bind synthetic H type 1, Leb, and H type 3, suggesting a potential mechanism for antibody-mediated neutralization of NV.

* Corresponding author. Mailing address: Department of Epidemiology, Program in Infectious Diseases, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7435. Phone: (919) 966-3895. Fax: (919) 966-2089. E-mail: rbaric{at}sph.unc.edu.

Journal of Virology, December 2002, p. 12335-12343, Vol. 76, No. 23
0022-538X/02/$04.00+0     DOI: 10.1128/JVI.76.23.12335-12343.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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