This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Brack, K.
Right arrow Articles by Vallbracht, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Brack, K.
Right arrow Articles by Vallbracht, A.

 Previous Article  |  Next Article 

Journal of Virology, December 2002, p. 11920-11930, Vol. 76, No. 23
0022-538X/02/$04.00+0     DOI: 10.1128/JVI.76.23.11920-11930.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Hepatitis A Virus Inhibits Cellular Antiviral Defense Mechanisms Induced by Double-Stranded RNA{dagger}

Kerstin Brack, Iris Berk, Thomas Magulski, Jörg Lederer, Andreas Dotzauer,* and Angelika Vallbracht

Department of Virology, University of Bremen, D-28359 Bremen, Germany

Received 28 May 2002/ Accepted 27 August 2002

The consequences of a hepatitis A virus (HAV) infection on cell-based antiviral responses and the interactions between virus and host cells resulting in persistent infections are poorly understood. In this report, we show that HAV does inhibit double-stranded (dsRNA)-induced beta interferon (IFN-ß) gene expression by influencing the IFN-ß enhanceosome, as well as dsRNA-induced apoptosis, which suggests that both effects may be connected by shared viral and/or cellular factors. This ability of HAV, which preserves the sites of virus production for a longer time, may allow the virus to establish an infection and may be the presupposition for setting up persistent infections. Our results suggest that the inhibitory effect of HAV on the cellular defense mechanisms might not be sufficient to completely prevent the antiviral reactions, which may be induced by accumulating viral dsRNA, at a later stage of infection. However, HAV seems to counteract this situation by downregulation of viral replication and in the following production of viral dsRNA. This ability of noncytopathogenic HAV acts dominantly on cytopathogenic HAV in trans. The downregulation might ensure the moderate replication which seems necessary for inhibition of the antiviral mechanisms by HAV and therefore for the persistent state of the HAV infection.

* Corresponding author. Mailing address: Department of Virology, University of Bremen, Leobener Strasse/UFT, D-28359 Bremen, Germany. Phone: 49-421-218-4354. Fax: 49-421-218-4266. E-mail: dotzauer{at}uni-bremen.de.

{dagger} This work is dedicated to H.-J. Gerth on the occasion of his 75th birthday.

Journal of Virology, December 2002, p. 11920-11930, Vol. 76, No. 23
0022-538X/02/$04.00+0     DOI: 10.1128/JVI.76.23.11920-11930.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Paulmann, D., Magulski, T., Schwarz, R., Heitmann, L., Flehmig, B., Vallbracht, A., Dotzauer, A. (2008). Hepatitis A virus protein 2B suppresses beta interferon (IFN) gene transcription by interfering with IFN regulatory factor 3 activation. J. Gen. Virol. 89: 1593-1604 [Abstract] [Full Text]  
  • Zhang, B., Morace, G., Gauss-Muller, V., Kusov, Y. (2007). Poly(A) binding protein, C-terminally truncated by the hepatitis A virus proteinase 3C, inhibits viral translation. Nucleic Acids Res 35: 5975-5984 [Abstract] [Full Text]  
  • Muller, S., Geffers, R., Gunther, S. (2007). Analysis of gene expression in Lassa virus-infected HuH-7 cells. J. Gen. Virol. 88: 1568-1575 [Abstract] [Full Text]  
  • Yang, Y., Liang, Y., Qu, L., Chen, Z., Yi, M., Li, K., Lemon, S. M. (2007). Disruption of innate immunity due to mitochondrial targeting of a picornaviral protease precursor. Proc. Natl. Acad. Sci. USA 104: 7253-7258 [Abstract] [Full Text]  
  • Kusov, Y., Kanda, T., Palmenberg, A., Sgro, J.-Y., Gauss-Muller, V. (2006). Silencing of Hepatitis A Virus Infection by Small Interfering RNAs.. J. Virol. 80: 5599-5610 [Abstract] [Full Text]  
  • Fensterl, V., Grotheer, D., Berk, I., Schlemminger, S., Vallbracht, A., Dotzauer, A. (2005). Hepatitis A Virus Suppresses RIG-I-Mediated IRF-3 Activation To Block Induction of Beta Interferon. J. Virol. 79: 10968-10977 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»