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Journal of Virology, November 2002, p. 11753-11756, Vol. 76, No. 22
0022-538X/02/$04.00+0     DOI: 10.1128/JVI.76.22.11753-11756.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

The Human Cytomegalovirus US10 Gene Product Delays Trafficking of Major Histocompatibility Complex Class I Molecules

Margo H. Furman, Neelendu Dey, Domenico Tortorella, and Hidde L. Ploegh*

Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115

Received 10 May 2002/ Accepted 12 August 2002

Human cytomegalovirus (HCMV) US10 encodes a glycoprotein that binds to major histocompatibility complex (MHC) class I heavy chains. While expression of US10 delays the normal trafficking of MHC class I molecules out of the endoplasmic reticulum, US10 does not obviously facilitate or inhibit the action of two other HCMV-encoded MHC class I binding proteins, US2 and US11.

* Corresponding author. Mailing address: Department of Pathology, Armenise Bldg., Rm. 137, Harvard Medical School, 200 Longwood Ave., Boston, MA 02115. Phone: (617) 432-4776. Fax: (617) 432-4775. E-mail: ploegh{at}hms.harvard.edu.

Journal of Virology, November 2002, p. 11753-11756, Vol. 76, No. 22
0022-538X/02/$04.00+0     DOI: 10.1128/JVI.76.22.11753-11756.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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