This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Vogel, T. U.
Right arrow Articles by Watkins, D. I.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Vogel, T. U.
Right arrow Articles by Watkins, D. I.

 Previous Article  |  Next Article 

Journal of Virology, November 2002, p. 11623-11636, Vol. 76, No. 22
0022-538X/02/$04.00+0     DOI: 10.1128/JVI.76.22.11623-11636.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Escape in One of Two Cytotoxic T-Lymphocyte Epitopes Bound by a High-Frequency Major Histocompatibility Complex Class I Molecule, Mamu-A*02: a Paradigm for Virus Evolution and Persistence?

Thorsten U. Vogel,1 Thomas C. Friedrich,1 David H. O'Connor,1 William Rehrauer,2 Elizabeth J. Dodds,1 Heather Hickman,3 William Hildebrand,3 John Sidney,4 Alessandro Sette,4 Austin Hughes,5 Helen Horton,1 Kathy Vielhuber,1 Richard Rudersdorf,1 Ivna P. de Souza,6 Matthew R. Reynolds,1 Todd M. Allen,1 Nancy Wilson,1 and David I. Watkins1,6*

Wisconsin Regional Primate Research Center,1 Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison, Wisconsin 53715,6 Laboratory of Histocompatibility/Molecular Diagnostics, University of Wisconsin Hospital and Clinics, Madison, Wisconsin 53792,2 Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73190,3 Epimmune, Inc., San Diego, California 92121,4 Department of Biological Sciences, University of South Carolina, Columbia, South Carolina 292085

Received 2 August 2002/ Accepted 13 August 2002

It is now accepted that an effective vaccine against AIDS must include effective cytotoxic-T-lymphocyte (CTL) responses. The simian immunodeficiency virus (SIV)-infected rhesus macaque is the best available animal model for AIDS, but analysis of macaque CTL responses has hitherto focused mainly on epitopes bound by a single major histocompatibility complex (MHC) class I molecule, Mamu-A*01. The availability of Mamu-A*01-positive macaques for vaccine studies is therefore severely limited. Furthermore, it is becoming clear that different CTL responses are able to control immunodeficiency virus replication with varying success, making it a priority to identify and analyze CTL responses restricted by common MHC class I molecules other than Mamu-A*01. Here we describe two novel epitopes derived from SIV, one from Gag (Gag71-79 GY9), and one from the Nef protein (Nef159-167 YY9). Both epitopes are bound by the common macaque MHC class I molecule, Mamu-A*02. The sequences of these two eptiopes are consistent with the molecule's peptide-binding motif, which we have defined by elution of natural ligands from Mamu-A*02. Strikingly, we found evidence for the selection of escape variant viruses by CTL specific for Nef159-167 YY9 in 6 of 6 Mamu-A*02-positive animals. In contrast, viral sequences encoding the Gag71-79 GY9 epitope remained intact in each animal. This situation is reminiscent of Mamu-A*01-restricted CTL that recognize Tat28-35 SL8, which reproducibly selects for escape variants during acute infection, and Gag181-189 CM9, which does not. Differential selection by CTL may therefore be a paradigm of immunodeficiency virus infection.

* Corresponding author. Mailing address: Wisconsin Regional Primate Research Center, 1220 Capitol Ct., Madison, WI 53715. Phone: (608) 265-3380. Fax (608) 265-8084. E-mail: watkins{at}primate.wisc.edu.

Journal of Virology, November 2002, p. 11623-11636, Vol. 76, No. 22
0022-538X/02/$04.00+0     DOI: 10.1128/JVI.76.22.11623-11636.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Kubo, M., Nishimura, Y., Shingai, M., Lee, W., Brenchley, J., Lafont, B., Buckler-White, A., Igarashi, T., Martin, M. A. (2009). Initiation of Antiretroviral Therapy 48 Hours after Infection with Simian Immunodeficiency Virus Potently Suppresses Acute-Phase Viremia and Blocks the Massive Loss of Memory CD4+ T Cells but Fails To Prevent Disease. J. Virol. 83: 7099-7108 [Abstract] [Full Text]  
  • Burwitz, B. J., Pendley, C. J., Greene, J. M., Detmer, A. M., Lhost, J. J., Karl, J. A., Piaskowski, S. M., Rudersdorf, R. A., Wallace, L. T., Bimber, B. N., Loffredo, J. T., Cox, D. G., Bardet, W., Hildebrand, W., Wiseman, R. W., O'Connor, S. L., O'Connor, D. H. (2009). Mauritian Cynomolgus Macaques Share Two Exceptionally Common Major Histocompatibility Complex Class I Alleles That Restrict Simian Immunodeficiency Virus-Specific CD8+ T Cells. J. Virol. 83: 6011-6019 [Abstract] [Full Text]  
  • Reynolds, M. R., Weiler, A. M., Weisgrau, K. L., Piaskowski, S. M., Furlott, J. R., Weinfurter, J. T., Kaizu, M., Soma, T., Leon, E. J., MacNair, C., Leaman, D. P., Zwick, M. B., Gostick, E., Musani, S. K., Price, D. A., Friedrich, T. C., Rakasz, E. G., Wilson, N. A., McDermott, A. B., Boyle, R., Allison, D. B., Burton, D. R., Koff, W. C., Watkins, D. I. (2008). Macaques vaccinated with live-attenuated SIV control replication of heterologous virus. JEM 205: 2537-2550 [Abstract] [Full Text]  
  • Maness, N. J., Yant, L. J., Chung, C., Loffredo, J. T., Friedrich, T. C., Piaskowski, S. M., Furlott, J., May, G. E., Soma, T., Leon, E. J., Wilson, N. A., Piontkivska, H., Hughes, A. L., Sidney, J., Sette, A., Watkins, D. I. (2008). Comprehensive Immunological Evaluation Reveals Surprisingly Few Differences between Elite Controller and Progressor Mamu-B*17-Positive Simian Immunodeficiency Virus-Infected Rhesus Macaques. J. Virol. 82: 5245-5254 [Abstract] [Full Text]  
  • Loffredo, J. T., Bean, A. T., Beal, D. R., Leon, E. J., May, G. E., Piaskowski, S. M., Furlott, J. R., Reed, J., Musani, S. K., Rakasz, E. G., Friedrich, T. C., Wilson, N. A., Allison, D. B., Watkins, D. I. (2008). Patterns of CD8+ Immunodominance May Influence the Ability of Mamu-B*08-Positive Macaques To Naturally Control Simian Immunodeficiency Virus SIVmac239 Replication. J. Virol. 82: 1723-1738 [Abstract] [Full Text]  
  • Valentine, L. E., Piaskowski, S. M., Rakasz, E. G., Henry, N. L., Wilson, N. A., Watkins, D. I. (2008). Recognition of Escape Variants in ELISPOT Does Not Always Predict CD8+ T-Cell Recognition of Simian Immunodeficiency Virus-Infected Cells Expressing the Same Variant Sequences. J. Virol. 82: 575-581 [Abstract] [Full Text]  
  • Harari, A., Cellerai, C., Enders, F. B., Kostler, J., Codarri, L., Tapia, G., Boyman, O., Castro, E., Gaudieri, S., James, I., John, M., Wagner, R., Mallal, S., Pantaleo, G. (2007). Skewed association of polyfunctional antigen-specific CD8 T cell populations with HLA-B genotype. Proc. Natl. Acad. Sci. USA 104: 16233-16238 [Abstract] [Full Text]  
  • Lichterfeld, M., Yu, X. G., Mui, S. K., Williams, K. L., Trocha, A., Brockman, M. A., Allgaier, R. L., Waring, M. T., Koibuchi, T., Johnston, M. N., Cohen, D., Allen, T. M., Rosenberg, E. S., Walker, B. D., Altfeld, M. (2007). Selective Depletion of High-Avidity Human Immunodeficiency Virus Type 1 (HIV-1)-Specific CD8+ T Cells after Early HIV-1 Infection. J. Virol. 81: 4199-4214 [Abstract] [Full Text]  
  • Asquith, B., McLean, A. R. (2007). In vivo CD8+ T cell control of immunodeficiency virus infection in humans and macaques. Proc. Natl. Acad. Sci. USA 104: 6365-6370 [Abstract] [Full Text]  
  • Friedrich, T. C., Valentine, L. E., Yant, L. J., Rakasz, E. G., Piaskowski, S. M., Furlott, J. R., Weisgrau, K. L., Burwitz, B., May, G. E., Leon, E. J., Soma, T., Napoe, G., Capuano, S. V. III, Wilson, N. A., Watkins, D. I. (2007). Subdominant CD8+ T-Cell Responses Are Involved in Durable Control of AIDS Virus Replication. J. Virol. 81: 3465-3476 [Abstract] [Full Text]  
  • Loffredo, J. T., Burwitz, B. J., Rakasz, E. G., Spencer, S. P., Stephany, J. J., Giraldo Vela, J. P., Martin, S. R., Reed, J., Piaskowski, S. M., Furlott, J., Weisgrau, K. L., Rodrigues, D. S., Soma, T., Napoe, G., Friedrich, T. C., Wilson, N. A., Kallas, E. G., Watkins, D. I. (2007). The Antiviral Efficacy of Simian Immunodeficiency Virus-Specific CD8+ T Cells Is Unrelated to Epitope Specificity and Is Abrogated by Viral Escape. J. Virol. 81: 2624-2634 [Abstract] [Full Text]  
  • Chung, C., Lee, W., Loffredo, J. T., Burwitz, B., Friedrich, T. C., Giraldo Vela, J. P., Napoe, G., Rakasz, E. G., Wilson, N. A., Allison, D. B., Watkins, D. I. (2007). Not All Cytokine-Producing CD8+ T Cells Suppress Simian Immunodeficiency Virus Replication. J. Virol. 81: 1517-1523 [Abstract] [Full Text]  
  • Leslie, A., Price, D. A., Mkhize, P., Bishop, K., Rathod, A., Day, C., Crawford, H., Honeyborne, I., Asher, T. E., Luzzi, G., Edwards, A., Rosseau, C. M., Mullins, J. I., Tudor-Williams, G., Novelli, V., Brander, C., Douek, D. C., Kiepiela, P., Walker, B. D., Goulder, P. J. R. (2006). Differential Selection Pressure Exerted on HIV by CTL Targeting Identical Epitopes but Restricted by Distinct HLA Alleles from the Same HLA Supertype. J. Immunol. 177: 4699-4708 [Abstract] [Full Text]  
  • Wilson, N. A., Reed, J., Napoe, G. S., Piaskowski, S., Szymanski, A., Furlott, J., Gonzalez, E. J., Yant, L. J., Maness, N. J., May, G. E., Soma, T., Reynolds, M. R., Rakasz, E., Rudersdorf, R., McDermott, A. B., O'Connor, D. H., Friedrich, T. C., Allison, D. B., Patki, A., Picker, L. J., Burton, D. R., Lin, J., Huang, L., Patel, D., Heindecker, G., Fan, J., Citron, M., Horton, M., Wang, F., Liang, X., Shiver, J. W., Casimiro, D. R., Watkins, D. I. (2006). Vaccine-Induced Cellular Immune Responses Reduce Plasma Viral Concentrations after Repeated Low-Dose Challenge with Pathogenic Simian Immunodeficiency Virus SIVmac239.. J. Virol. 80: 5875-5885 [Abstract] [Full Text]  
  • Newberg, M. H., McEvers, K. J., Gorgone, D. A., Lifton, M. A., Baumeister, S. H. C., Veazey, R. S., Schmitz, J. E., Letvin, N. L. (2006). Immunodomination in the Evolution of Dominant Epitope-Specific CD8+ T Lymphocyte Responses in Simian Immunodeficiency Virus-Infected Rhesus Monkeys. J. Immunol. 176: 319-328 [Abstract] [Full Text]  
  • Loffredo, J. T., Rakasz, E. G., Giraldo, J. P., Spencer, S. P., Grafton, K. K., Martin, S. R., Napoe, G., Yant, L. J., Wilson, N. A., Watkins, D. I. (2005). Tat28-35SL8-Specific CD8+ T Lymphocytes Are More Effective than Gag181-189CM9-Specific CD8+ T Lymphocytes at Suppressing Simian Immunodeficiency Virus Replication in a Functional In Vitro Assay. J. Virol. 79: 14986-14991 [Abstract] [Full Text]  
  • Loffredo, J. T., Sidney, J., Piaskowski, S., Szymanski, A., Furlott, J., Rudersdorf, R., Reed, J., Peters, B., Hickman-Miller, H. D., Bardet, W., Rehrauer, W. M., O'Connor, D. H., Wilson, N. A., Hildebrand, W. H., Sette, A., Watkins, D. I. (2005). The High Frequency Indian Rhesus Macaque MHC Class I Molecule, Mamu-B*01, Does Not Appear to Be Involved in CD8+ T Lymphocyte Responses to SIVmac239. J. Immunol. 175: 5986-5997 [Abstract] [Full Text]  
  • Hickman-Miller, H. D., Bardet, W., Gilb, A., Luis, A. D., Jackson, K. W., Watkins, D. I., Hildebrand, W. H. (2005). Rhesus Macaque MHC Class I Molecules Present HLA-B-Like Peptides. J. Immunol. 175: 367-375 [Abstract] [Full Text]  
  • Su, J., Luscher, M. A., Xiong, Y., Rustam, T., Amara, R. R., Rakasz, E., Robinson, H. L., MacDonald, K. S. (2005). Novel simian immunodeficiency virus CTL epitopes restricted by MHC class I molecule Mamu-B*01 are highly conserved for long term in DNA/MVA-vaccinated, SHIV-challenged rhesus macaques. Int Immunol 17: 637-648 [Abstract] [Full Text]  
  • Seaman, M. S., Santra, S., Newberg, M. H., Philippon, V., Manson, K., Xu, L., Gelman, R. S., Panicali, D., Mascola, J. R., Nabel, G. J., Letvin, N. L. (2005). Vaccine-Elicited Memory Cytotoxic T Lymphocytes Contribute to Mamu-A*01-Associated Control of Simian/Human Immunodeficiency Virus 89.6P Replication in Rhesus Monkeys. J. Virol. 79: 4580-4588 [Abstract] [Full Text]  
  • Otting, N., Heijmans, C. M. C., Noort, R. C., de Groot, N. G., Doxiadis, G. G. M., van Rood, J. J., Watkins, D. I., Bontrop, R. E. (2005). Unparalleled complexity of the MHC class I region in rhesus macaques. Proc. Natl. Acad. Sci. USA 102: 1626-1631 [Abstract] [Full Text]  
  • Dale, C. J., De Rose, R., Stratov, I., Chea, S., Montefiori, D. C., Thomson, S., Ramshaw, I. A., Coupar, B. E. H., Boyle, D. B., Law, M., Kent, S. J. (2004). Efficacy of DNA and Fowlpox Virus Priming/Boosting Vaccines for Simian/Human Immunodeficiency Virus. J. Virol. 78: 13819-13828 [Abstract] [Full Text]  
  • O'Connor, D. H., McDermott, A. B., Krebs, K. C., Dodds, E. J., Miller, J. E., Gonzalez, E. J., Jacoby, T. J., Yant, L., Piontkivska, H., Pantophlet, R., Burton, D. R., Rehrauer, W. M., Wilson, N., Hughes, A. L., Watkins, D. I. (2004). A Dominant Role for CD8+-T-Lymphocyte Selection in Simian Immunodeficiency Virus Sequence Variation. J. Virol. 78: 14012-14022 [Abstract] [Full Text]  
  • Loffredo, J. T., Sidney, J., Wojewoda, C., Dodds, E., Reynolds, M. R., Napoe, G., Mothe, B. R., O'Connor, D. H., Wilson, N. A., Watkins, D. I., Sette, A. (2004). Identification of Seventeen New Simian Immunodeficiency Virus-Derived CD8+ T Cell Epitopes Restricted by the High Frequency Molecule, Mamu-A*02, and Potential Escape from CTL Recognition. J. Immunol. 173: 5064-5076 [Abstract] [Full Text]  
  • Friedrich, T. C., McDermott, A. B., Reynolds, M. R., Piaskowski, S., Fuenger, S., de Souza, I. P., Rudersdorf, R., Cullen, C., Yant, L. J., Vojnov, L., Stephany, J., Martin, S., O'Connor, D. H., Wilson, N., Watkins, D. I. (2004). Consequences of Cytotoxic T-Lymphocyte Escape: Common Escape Mutations in Simian Immunodeficiency Virus Are Poorly Recognized in Naive Hosts. J. Virol. 78: 10064-10073 [Abstract] [Full Text]  
  • Mackay, G. A., Liu, Z., Singh, D. K., Smith, M. S., Mukherjee, S., Sheffer, D., Jia, F., Adany, I., Sun, K. H., Dhillon, S., Zhuge, W., Narayan, O. (2004). Protection Against Late-Onset AIDS in Macaques Prophylactically Immunized with a Live Simian HIV Vaccine Was Dependent on Persistence of the Vaccine Virus. J. Immunol. 173: 4100-4107 [Abstract] [Full Text]  
  • de Groot, N., Doxiadis, G. G., de Groot, N. G., Otting, N., Heijmans, C., Rouweler, A. J. M., Bontrop, R. E. (2004). Genetic Makeup of the DR Region in Rhesus Macaques: Gene Content, Transcripts, and Pseudogenes. J. Immunol. 172: 6152-6157 [Abstract] [Full Text]  
  • Prieur, E., Gilbert, S. C., Schneider, J., Moore, A. C., Sheu, E. G., Goonetilleke, N., Robson, K. J. H., Hill, A. V. S. (2004). A Plasmodium falciparum candidate vaccine based on a six-antigen polyprotein encoded by recombinant poxviruses. Proc. Natl. Acad. Sci. USA 101: 290-295 [Abstract] [Full Text]  
  • Vogel, T. U., Reynolds, M. R., Fuller, D. H., Vielhuber, K., Shipley, T., Fuller, J. T., Kunstman, K. J., Sutter, G., Marthas, M. L., Erfle, V., Wolinsky, S. M., Wang, C., Allison, D. B., Rud, E. W., Wilson, N., Montefiori, D., Altman, J. D., Watkins, D. I. (2003). Multispecific Vaccine-Induced Mucosal Cytotoxic T Lymphocytes Reduce Acute-Phase Viral Replication but Fail in Long-Term Control of Simian Immunodeficiency Virus SIVmac239. J. Virol. 77: 13348-13360 [Abstract] [Full Text]  
  • Brown, K., Gao, W., Alber, S., Trichel, A., Murphey-Corb, M., Watkins, S. C., Gambotto, A., Barratt-Boyes, S. M. (2003). Adenovirus-Transduced Dendritic Cells Injected into Skin or Lymph Node Prime Potent Simian Immunodeficiency Virus-Specific T Cell Immunity in Monkeys. J. Immunol. 171: 6875-6882 [Abstract] [Full Text]  
  • Wilson, C. C., McKinney, D., Anders, M., MaWhinney, S., Forster, J., Crimi, C., Southwood, S., Sette, A., Chesnut, R., Newman, M. J., Livingston, B. D. (2003). Development of a DNA Vaccine Designed to Induce Cytotoxic T Lymphocyte Responses to Multiple Conserved Epitopes in HIV-1. J. Immunol. 171: 5611-5623 [Abstract] [Full Text]  
  • Yang, O. O., Sarkis, P. T. N., Trocha, A., Kalams, S. A., Johnson, R. P., Walker, B. D. (2003). Impacts of Avidity and Specificity on the Antiviral Efficiency of HIV-1-Specific CTL. J. Immunol. 171: 3718-3724 [Abstract] [Full Text]  
  • O'Connor, D. H., Mothe, B. R., Weinfurter, J. T., Fuenger, S., Rehrauer, W. M., Jing, P., Rudersdorf, R. R., Liebl, M. E., Krebs, K., Vasquez, J., Dodds, E., Loffredo, J., Martin, S., McDermott, A. B., Allen, T. M., Wang, C., Doxiadis, G. G., Montefiori, D. C., Hughes, A., Burton, D. R., Allison, D. B., Wolinsky, S. M., Bontrop, R., Picker, L. J., Watkins, D. I. (2003). Major Histocompatibility Complex Class I Alleles Associated with Slow Simian Immunodeficiency Virus Disease Progression Bind Epitopes Recognized by Dominant Acute-Phase Cytotoxic-T-Lymphocyte Responses. J. Virol. 77: 9029-9040 [Abstract] [Full Text]  
  • Lafont, B. A. P., Buckler-White, A., Plishka, R., Buckler, C., Martin, M. A. (2003). Characterization of Pig-Tailed Macaque Classical MHC Class I Genes: Implications for MHC Evolution and Antigen Presentation in Macaques. J. Immunol. 171: 875-885 [Abstract] [Full Text]  
  • Yang, O. O., Sarkis, P. T. N., Ali, A., Harlow, J. D., Brander, C., Kalams, S. A., Walker, B. D. (2003). Determinants of HIV-1 Mutational Escape From Cytotoxic T Lymphocytes. JEM 197: 1365-1375 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»