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Journal of Virology, November 2002, p. 11172-11175, Vol. 76, No. 21
0022-538X/02/$04.00+0     DOI: 10.1128/JVI.76.21.11172-11175.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Regions of Mouse Mammary Tumor Virus Superantigen Involved in Interaction with the Major Histocompatibility Complex Class II I-A Molecule

Susanne Wirth,1* Annelyse Vessaz,1 Claude Krummenacher,1 Frédéric Baribaud,1 Hans Acha-Orbea,2,3 and Heidi Diggelmann1

Institute of Microbiology, University of Lausanne, CH-1011 Lausanne,1 Institute of Biochemistry, University of Lausanne,2 Ludwig Institute for Cancer Research, Lausanne Branch, CH-1066 Epalinges, Switzerland3

Received 1 May 2002/ Accepted 6 July 2002

To study the major histocompatibility complex class II I-E dependence of mouse mammary tumor virus (MMTV) superantigens, we constructed hybrids between the I-E-dependent MMTV(GR) and the I-E-independent mtv-7 superantigens and tested them in vivo. Our results suggest that, although the C-terminal third mediates I-A interaction, additional binding sites are located elsewhere in the superantigen.

* Corresponding author. Mailing address: Institute of Microbiology, 44, Rue du Bugnon, CH-1011 Lausanne, Switzerland. Phone: (41) 21 314 40 79. Fax: (41) 314 40 95. E-mail: Susanne.Wirth-dulex{at}chuv.hospvd.ch.

Journal of Virology, November 2002, p. 11172-11175, Vol. 76, No. 21
0022-538X/02/$04.00+0     DOI: 10.1128/JVI.76.21.11172-11175.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.





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