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Journal of Virology, November 2002, p. 11148-11154, Vol. 76, No. 21
0022-538X/02/$04.00+0     DOI: 10.1128/JVI.76.21.11148-11154.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Comparative Analysis of Anti-Hepatitis C Virus Activity and Gene Expression Mediated by Alpha, Beta, and Gamma Interferons

I. Wayne Cheney, Vicky C. H. Lai, Weidong Zhong, Tessa Brodhag, Shannon Dempsey, Charmaine Lim, Zhi Hong, Johnson Y. N. Lau, and Robert C. Tam*

Ribapharm, Inc., Costa Mesa, California 92626

Received 22 April 2002/ Accepted 23 July 2002

A direct comparison of the inhibitory effects of alpha, beta, and gamma interferons (IFNs) on replication of a hepatitis C virus subgenomic replicon in a hepatoma cell line revealed similarities in antiviral potency. However, alternate IFN-induced antiviral mechanisms were suggested following observations of striking differences between IFN-{gamma} and IFN-{alpha}/ß with respect to strength and durability of the antiviral response and the magnitude and pattern of IFN-mediated gene expression.

* Corresponding author. Mailing address: Ribapharm, Inc., 3300 Hyland Ave., Costa Mesa, CA 92626. Phone: (714) 545-0100. Fax: (714) 668-3141. E-mail: rtam{at}ribapharm.com.

Journal of Virology, November 2002, p. 11148-11154, Vol. 76, No. 21
0022-538X/02/$04.00+0     DOI: 10.1128/JVI.76.21.11148-11154.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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