This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Gáspár, G.
Right arrow Articles by Neyts, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Gáspár, G.
Right arrow Articles by Neyts, J.

 Previous Article  |  Next Article 

Journal of Virology, October 2002, p. 10530-10532, Vol. 76, No. 20
0022-538X/02/$04.00+0     DOI: 10.1128/JVI.76.20.10530-10532.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Human Herpesvirus 8 Gene Encodes a Functional Thymidylate Synthase

Gábor Gáspár,1,2 Erik De Clercq,1 and Johan Neyts1*

Rega Institute for Medical Research, Leuven, Belgium,1 Department of Medical Microbiology, University of Szeged, Szeged, Hungary2

Received 15 May 2002/ Accepted 11 July 2002

We demonstrate that human herpesvirus 8, obtained from the lymphoma cell line BC-3 as well as from Kaposi's sarcoma lesions, carries a gene that encodes a functional thymidylate synthase (TS). The particular characteristics of this enzyme are studied and compared to the characteristics of TSs encoded by other organisms.

* Corresponding author. Mailing address: Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, B-3000 Leuven, Belgium. Phone: 32-16-337341. Fax: 32-16-337340. E-mail: Johan.Neyts{at}rega.kuleuven.ac.be.

Journal of Virology, October 2002, p. 10530-10532, Vol. 76, No. 20
0022-538X/02/$04.00+0     DOI: 10.1128/JVI.76.20.10530-10532.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Zhu, W., Burnette, A., Dorjsuren, D., Roberts, P. E., Huleihel, M., Shoemaker, R. H., Marquez, V. E., Agbaria, R., Sei, S. (2005). Potent Antiviral Activity of North-Methanocarbathymidine against Kaposi's Sarcoma-Associated Herpesvirus. Antimicrob. Agents Chemother. 49: 4965-4973 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»