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Journal of Virology, October 2002, p. 10507-10511, Vol. 76, No. 20
0022-538X/02/$04.00+0     DOI: 10.1128/JVI.76.20.10507-10511.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Effects of Cytotoxic T Lymphocytes (CTL) Directed against a Single Simian Immunodeficiency Virus (SIV) Gag CTL Epitope on the Course of SIVmac239 Infection

Todd M. Allen,1* Peicheng Jing,1 Briana Calore,1 Helen Horton,1 David H. O'Connor,1 Tomas Hanke,2 Marian Piekarczyk,1 Richard Ruddersdorf,1 Bianca R. Mothé,1 Carol Emerson,1 Nancy Wilson,1 Jeffrey D. Lifson,3 Igor M. Belyakov,4 Jay A. Berzofsky,4 Chenxi Wang,5 David B. Allison,5 David C. Montefiori,6 Ronald C. Desrosiers,7 Steven Wolinsky,8 Kevin J. Kunstman,8 John D. Altman,9 Alessandro Sette,10 Andrew J. McMichael,2 and David I. Watkins1,11

Wisconsin Regional Primate Research Center, University of Wisconsin, Madison, Wisconsin 53715,1 Institute of Molecular Medicine, John Radcliffe Hospital—Headington, Oxford OX3 9DS, United Kingdom,2 Retroviral Pathogenesis Laboratory, AIDS Vaccine Program, SAIC Frederick, Frederick Cancer Research and Development Center, National Cancer Institute, Frederick, Maryland 21702,3 National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892,4 Section on Statistical Genetics, Department of Biostatistics and Clinical Nutrition Research Center, University of Alabama—Birmingham, Birmingham, Alabama 35294,5 Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710,6 New England Regional Primate Research Center, Southborough, Massachusetts 01772,7 Northwestern University Medical School, Chicago, Illinois 60611-3010,8 Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia 30322,9 Epimmune Inc., San Diego, California 92121,10 Department of Pathology and Laboratory Medicine, University of Wisconsin Medical School, Madison, Wisconsin 53706,11

Received 23 April 2002/ Accepted 1 July 2002

Vaccine-induced cytotoxic T lymphocytes (CTL) have been implicated in the control of virus replication in simian immunodeficiency virus (SIV)-challenged and simian-human immunodeficiency virus-challenged macaques. Therefore, we wanted to test the impact that vaccine-induced CTL responses against an immunodominant Gag epitope might have in the absence of other immune responses. By themselves, these strong CTL responses failed to control SIVmac239 replication.

* Corresponding author. Mailing address: AIDS Research Center, Massachusetts General Hospital, Bldg. 149, 13th St., Charlestown, MA 02129. Phone: (617) 726-7846. Fax: (617) 726-5411. E-mail: tallen2{at}partners.org.

Journal of Virology, October 2002, p. 10507-10511, Vol. 76, No. 20
0022-538X/02/$04.00+0     DOI: 10.1128/JVI.76.20.10507-10511.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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