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Journal of Virology, October 2002, p. 10503-10506, Vol. 76, No. 20
0022-538X/02/$04.00+0     DOI: 10.1128/JVI.76.20.10503-10506.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

A Zebrafish Coxsackievirus and Adenovirus Receptor Homologue Interacts with Coxsackie B Virus and Adenovirus

JenniElizabeth Petrella, Christopher J. Cohen, Jedidiah Gaetz, and Jeffrey M. Bergelson*

Division of Immunologic and Infectious Diseases, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania

Received 7 May 2002/ Accepted 8 July 2002

In this study, a zebrafish homologue of the coxsackievirus and adenovirus receptor (CAR) protein was identified. Although the extracellular domain of zebrafish CAR (zCAR) is less than 50% identical to that of human CAR (hCAR), zCAR mediated infection of transfected cells by both adenovirus type 5 and coxsackievirus B3. CAR residues interacting deep within the coxsackievirus canyon are highly conserved in zCAR and hCAR, which is consistent with the idea that receptor contacts within the canyon are responsible for coxsackievirus attachment. In contrast, CAR residues contacting the south edge of the canyon are not conserved, suggesting that receptor interaction with the viral "puff region" is not essential for attachment.

* Corresponding author. Mailing address: Division of Immunologic and Infectious Diseases, Abramson 1202, The Children's Hospital of Philadelphia, 3615 Civic Center Blvd., Philadelphia, PA 19104. Phone: (215) 590-3771. Fax: (215) 590-2025. E-mail: bergelson{at}email.chop.edu.

Journal of Virology, October 2002, p. 10503-10506, Vol. 76, No. 20
0022-538X/02/$04.00+0     DOI: 10.1128/JVI.76.20.10503-10506.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.





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