This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Oxenius, A.
Right arrow Articles by Günthard, H. F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Oxenius, A.
Right arrow Articles by Günthard, H. F.

 Previous Article  |  Next Article 

Journal of Virology, October 2002, p. 10169-10176, Vol. 76, No. 20
0022-538X/02/$04.00+0     DOI: 10.1128/JVI.76.20.10169-10176.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Human Immunodeficiency Virus-Specific CD8+ T-Cell Responses Do Not Predict Viral Growth and Clearance Rates during Structured Intermittent Antiretroviral Therapy

Annette Oxenius,1 Angela R. McLean,2 Marek Fischer,3 David A. Price,1 Sarah J. Dawson,1 Roland Hafner,3 Christine Schneider,3 Helen Joller,4 Bernard Hirschel,5 Rodney E. Phillips,1 Rainer Weber,3 Huldrych F. Günthard,3,{dagger}* and for the Swiss HIV Cohort Study Group

Nuffield Department of Clinical Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU,1 Department of Zoology, University of Oxford, Oxford OX1 3PS, United Kingdom,2 Division of Infectious Diseases,3 Clinical Immunology, Department of Medicine, University Hospital Zurich, 8091 Zurich,4 Division of Infectious Diseases, University Hospital Geneva, 1211 Geneva, Switzerland5

Received 11 March 2002/ Accepted 8 July 2002

There is a continuing search for better ways to use existing drugs against human immunodeficiency virus (HIV). One idea is to use short therapy interruptions to "autovaccinate" HIV-infected patients. A group of 13 chronically HIV-infected patients enrolled in a trial of such so-called structured treatment interruptions (STIs) were intensively studied with respect to their viral load (VL) and HIV-specific CD8+ T-cell (cytotoxic T-lymphocyte [CTL]) responses. We found that 10 of the 13 patients had plateau VLs after STIs that were lower than their pretreatment VLs. While viral rebound rates became lower over STIs, there were no changes in clearance rates. Although numbers of CTLs did increase over the same time that viral rebounds decreased, there was no correlation between CTL count and either viral rebound rates or clearance rates. Finally, we asked whether absolute numbers of or changes in numbers of CTLs predict plateau VLs after STIs. No measure of CTLs was able to predict plateau VLs. Thus, there was no signature in these data of an important contribution to virological control from HIV-specific CD8+ T lymphocytes.

* Corresponding author. Mailing address: University Hospital Zurich, Division of Infectious Diseases and Hospital Epidemiology, Rämistrasse 100, CH-8091 Zürich, Switzerland. Phone: 41 1 255 34 50. Fax: 41 1 255 32 91. E-mail: huldrych.guenthard{at}dim.usz.ch.

{dagger} The members of the Swiss HIV Cohort Study Group are as follows: M. Battegay and H. Bucher, University Hospital Basel, Basel; E. Bernasconi and J.-C. Piffaretti, Ospedale Civico Lugano, Lugano; P. Bürgisser, P. Francioli, G. Pantaleo, M. Rickenbach, and A. Telenti, University Hospital Lausanne, Lausanne; M. Egger, University of Bern, Bern; P. Erb and T. Klimkait, University of Basel, Basel; W. Fierz, P. Vernazza, and T. Wagels, Kantonsspital St. Gallen, St. Gallen; M. Fischer, M. Flepp, H. Günthard, P. Grob, B. Ledergerber, U. Lauper, M. Opravil, R. Speck, A. Trkola, and R. Weber, University Hospital Zurich, Zurich; H. J. Furrer and M. Gorgievski, University Hospital Bern, Bern; B. Hirschel, L. Kaiser, L. Perrin, and S. Yerly, University Hospital Geneva, Geneva; C. Kind, Kantonsspital St. Gallen, St. Gallen; F. Paccaud, University of Lausanne, Lausanne; C. Rudin, Kantonsspital Liestal, Liestal; and J. Schüpbach, University of Zurich, Zurich.

Journal of Virology, October 2002, p. 10169-10176, Vol. 76, No. 20
0022-538X/02/$04.00+0     DOI: 10.1128/JVI.76.20.10169-10176.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Fryer, H. R., Scherer, A., Oxenius, A., Phillips, R., McLean, A. R. (2009). No evidence for competition between cytotoxic T-lymphocyte responses in HIV-1 infection. Proc R Soc B 276: 4389-4397 [Abstract] [Full Text]  
  • Rehr, M., Cahenzli, J., Haas, A., Price, D. A., Gostick, E., Huber, M., Karrer, U., Oxenius, A. (2008). Emergence of Polyfunctional CD8+ T Cells after Prolonged Suppression of Human Immunodeficiency Virus Replication by Antiretroviral Therapy. J. Virol. 82: 3391-3404 [Abstract] [Full Text]  
  • Rouzine, I. M., Sergeev, R. A., Glushtsov, A. I. (2006). Two types of cytotoxic lymphocyte regulation explain kinetics of immune response to human immunodeficiency virus. Proc. Natl. Acad. Sci. USA 103: 666-671 [Abstract] [Full Text]  
  • Joos, B., Trkola, A., Fischer, M., Kuster, H., Rusert, P., Leemann, C., Boni, J., Oxenius, A., Price, D. A., Phillips, R. E., Wong, J. K., Hirschel, B., Weber, R., Gunthard, H. F., the Swiss HIV Cohort Study, (2005). Low Human Immunodeficiency Virus Envelope Diversity Correlates with Low In Vitro Replication Capacity and Predicts Spontaneous Control of Plasma Viremia after Treatment Interruptions. J. Virol. 79: 9026-9037 [Abstract] [Full Text]  
  • Casazza, J. P., Betts, M. R., Hill, B. J., Brenchley, J. M., Price, D. A., Douek, D. C., Koup, R. A. (2005). Immunologic Pressure within Class I-Restricted Cognate Human Immunodeficiency Virus Epitopes during Highly Active Antiretroviral Therapy. J. Virol. 79: 3653-3663 [Abstract] [Full Text]  
  • Trkola, A., Kuster, H., Leemann, C., Oxenius, A., Fagard, C., Furrer, H., Battegay, M., Vernazza, P., Bernasconi, E., Weber, R., Hirschel, B., Bonhoeffer, S., Gunthard, H. F. (2004). Humoral immunity to HIV-1: kinetics of antibody responses in chronic infection reflects capacity of immune system to improve viral set point. Blood 104: 1784-1792 [Abstract] [Full Text]  
  • Scherer, A., Frater, J., Oxenius, A., Agudelo, J., Price, D. A., Gunthard, H. F., Barnardo, M., Perrin, L., Hirschel, B., Phillips, R. E., McLean, A. R., The Swiss HIV Cohort Study, (2004). From the Cover: Quantifiable cytotoxic T lymphocyte responses and HLA-related risk of progression to AIDS. Proc. Natl. Acad. Sci. USA 101: 12266-12270 [Abstract] [Full Text]  
  • Trkola, A., Kuster, H., Leemann, C., Ruprecht, C., Joos, B., Telenti, A., Hirschel, B., Weber, R., Bonhoeffer, S., Gunthard, H. F. (2003). Human Immunodeficiency Virus Type 1 Fitness Is a Determining Factor in Viral Rebound and Set Point in Chronic Infection. J. Virol. 77: 13146-13155 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»