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Journal of Virology, October 2002, p. 10074-10078, Vol. 76, No. 19
0022-538X/02/$04.00+0     DOI: 10.1128/JVI.76.19.10074-10078.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Asian Genotypes of JC Virus in Japanese-Americans Suggest Familial Transmission{dagger}

Makoto Suzuki,1,2* Huai-Ying Zheng,2,3 Tomokazu Takasaka,3 Chie Sugimoto,3 Tadaichi Kitamura,2 Ernest Beutler,1 and Yoshiaki Yogo3

Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037,1 Department of Urology, Faculty of Medicine, The University of Tokyo, Bunkyo-ku, 113-8655 Tokyo,2 Laboratory of Viral Infection, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Minato-ku, 108-8639 Tokyo, Japan3

Received 4 April 2002/ Accepted 24 June 2002

To examine the mode of JC virus (JCV) transmission, we collected urine samples from second- and third-generation Japanese-Americans in Los Angeles, Calif., whose parents and grandparents were all Japanese. From the urine samples of these Japanese-Americans, we mainly detected two subtypes (CY and MY) of JCV that are predominantly found among native Japanese. This finding provides support for the hypothesis that JCV is transmitted mainly within the family through long-term cohabitation.

* Corresponding author. Mailing address: Department of Urology, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113-8655 Tokyo, Japan. Phone: 81 3 5800 8662. Fax: 81 3 5800 8917. E-mail: msuzuki{at}scripps.edu.

{dagger} Manuscript 14110-MEM from The Scripps Research Institute.

Journal of Virology, October 2002, p. 10074-10078, Vol. 76, No. 19
0022-538X/02/$04.00+0     DOI: 10.1128/JVI.76.19.10074-10078.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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