This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Laskus, T.
Right arrow Articles by Rakela, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Laskus, T.
Right arrow Articles by Rakela, J.

 Previous Article  |  Next Article 

Journal of Virology, October 2002, p. 10064-10068, Vol. 76, No. 19
0022-538X/02/$04.00+0     DOI: 10.1128/JVI.76.19.10064-10068.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Detection and Analysis of Hepatitis C Virus Sequences in Cerebrospinal Fluid

Tomasz Laskus,1 Marek Radkowski,1,2 Agnieszka Bednarska,3 Jeffrey Wilkinson,1 Debra Adair,1 Marek Nowicki,4 Georgia B. Nikolopoulou,4 Hugo Vargas,1 and Jorge Rakela1*

Division of Transplantation Medicine, Mayo Clinic, Scottsdale, Arizona 85259,1 Institute of Infectious Diseases, Medical Academy,2 Municipal Hospital for Infectious Diseases, Warsaw, Poland,3 Maternal-Child Virology Research Laboratory, University of Southern California, Los Angeles, California 900334

Received 11 December 2001/ Accepted 25 June 2002

Hepatitis C virus (HCV) sequences were detected in cerebrospinal fluid (CSF) in 8 of 13 HCV-positive patients. In four patients harboring different virus strains in serum and peripheral blood mononuclear cells (PBMC), CSF-derived virus was similar to that found in PBMC, which suggests that PBMC could carry HCV into the brain.

* Corresponding author. Mailing address: Division of Transplantation Medicine, SC Johnson Bldg. Sj3, Mayo Clinic, Scottsdale, AZ 85259. Phone: (480) 301-4871. Fax: (480) 301-3384. E-mail: rakela.jorge{at}mayo.edu.

Journal of Virology, October 2002, p. 10064-10068, Vol. 76, No. 19
0022-538X/02/$04.00+0     DOI: 10.1128/JVI.76.19.10064-10068.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Wilkinson, J., Radkowski, M., Laskus, T. (2009). Hepatitis C Virus Neuroinvasion: Identification of Infected Cells. J. Virol. 83: 1312-1319 [Abstract] [Full Text]  
  • Li, H., Thomassen, L. V., Majid, A., McMahon, B. J., Bruden, D., McArdle, S., Bano, N., Chung, M., Carithers, R. L., Perkins, J. D., Sullivan, D. G., Gretch, D. R. (2008). Investigation of Putative Multisubtype Hepatitis C Virus Infections In Vivo by Heteroduplex Mobility Analysis of Core/Envelope Subgenomes. J. Virol. 82: 7524-7532 [Abstract] [Full Text]  
  • Hoftberger, R., Garzuly, F., Dienes, H.P., Grubits, J., Rohonyi, B., Fischer, G., Hanzely, Z., Lassmann, H., Budka, H. (2007). Fulminant central nervous system demyelination associated with interferon-{alpha} therapy and hepatitis C virus infection. Mult Scler 13: 1100-1106 [Abstract]  
  • Freudenreich, O., Gandhi, R. T., Walsh, J. P., Henderson, D. C., Goff, D. C. (2007). Hepatitis C in Schizophrenia: Screening Experience in a Community-Dwelling Clozapine Cohort. Psychosomatics 48: 405-411 [Abstract] [Full Text]  
  • Forton, D. M., Karayiannis, P., Mahmud, N., Taylor-Robinson, S. D., Thomas, H. C. (2004). Identification of Unique Hepatitis C Virus Quasispecies in the Central Nervous System and Comparative Analysis of Internal Translational Efficiency of Brain, Liver, and Serum Variants. J. Virol. 78: 5170-5183 [Abstract] [Full Text]  
  • Ryan, E.L., Morgello, S., Isaacs, K., Naseer, M., Gerits, P., the Manhattan HIV Brain Bank, (2004). Neuropsychiatric impact of hepatitis C on advanced HIV. Neurology 62: 957-962 [Abstract] [Full Text]  
  • Henderson, D. K. (2003). Managing Occupational Risks for Hepatitis C Transmission in the Health Care Setting. Clin. Microbiol. Rev. 16: 546-568 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»