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Journal of Virology, September 2002, p. 9537-9544, Vol. 76, No. 18
0022-538X/02/$04.00+0     DOI: 10.1128/JVI.76.18.9537-9544.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Growth of Rotaviruses in Primary Pancreatic Cells

Barbara S. Coulson,1* Paul D. Witterick,1,2 Yan Tan,1 Marilyn J. Hewish,1 Joanne N. Mountford,2 Leonard C. Harrison,2 and Margo C. Honeyman2

Department of Microbiology and Immunology, The University of Melbourne, Royal Parade, Victoria 3010,1 Autoimmunity and Transplantation Division, Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia2

Received 26 November 2001/ Accepted 12 June 2002

Rotavirus infection in children at risk of developing type 1 diabetes has been temporally associated with development of pancreatic islet autoantibodies. In this study, nonobese diabetic mice were shown to be susceptible to rhesus rotavirus infection and pancreatic islets from nonobese diabetic mice, nonobese diabetes-resistant mice, fetal pigs, and macaque monkeys supported various degrees of rotavirus growth. Human rotaviruses replicated in monkey islets only. This islet susceptibility shows that rotavirus infection of the pancreas in vivo might be possible.

* Corresponding author. Mailing address: Department of Microbiology and Immunology, The University of Melbourne, Royal Parade, Victoria 3010, Australia. Phone: 61 3 8344 8823. Fax: 61 3 9347 1540. E-mail: barbarac{at}unimelb.edu.au.

Journal of Virology, September 2002, p. 9537-9544, Vol. 76, No. 18
0022-538X/02/$04.00+0     DOI: 10.1128/JVI.76.18.9537-9544.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Graham, K. L., Sanders, N., Tan, Y., Allison, J., Kay, T. W. H., Coulson, B. S. (2008). Rotavirus Infection Accelerates Type 1 Diabetes in Mice with Established Insulitis. J. Virol. 82: 6139-6149 [Abstract] [Full Text]  
  • Graham, K. L., O'Donnell, J. A., Tan, Y., Sanders, N., Carrington, E. M., Allison, J., Coulson, B. S. (2007). Rotavirus Infection of Infant and Young Adult Nonobese Diabetic Mice Involves Extraintestinal Spread and Delays Diabetes Onset. J. Virol. 81: 6446-6458 [Abstract] [Full Text]  
  • Ramig, R. F. (2004). Pathogenesis of Intestinal and Systemic Rotavirus Infection. J. Virol. 78: 10213-10220 [Full Text]  
  • Qiao, H., Clark, H. F., DiVietro, M., Riepenhoff-Talty, M. (2004). A comparison of the effects of oral inoculation with Rotashield and pentavalent reassortant rotavirus vaccine (WC3-PV) on suckling CB17scid mice. J. Gen. Virol. 85: 2245-2253 [Abstract] [Full Text]  


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