This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Zhang, L. Articles by Ho, D. D. Search for Related Content PubMed PubMed Citation Articles by Zhang, L. Articles by Ho, D. D.

Compartmentalization of Surface Envelope Glycoprotein of Human Immunodeficiency Virus Type 1 during Acute and Chronic Infection

Aaron Diamond AIDS Research Center, The Rockefeller University, New York, New York 10016

Received 11 March 2002/ Accepted 7 June 2002

Human immunodeficiency virus type 1 is characterized by extensive genetic heterogeneity. Having previously demonstrated that, in the peripheral blood, the initial viral population is more homogeneous than at subsequent stages of infection, we have extended our studies to tissue samples, allowing comparisons between viral populations in peripheral blood and tissues during both the acute and chronic stages of infection. We found that homogeneity in gp120 sequences during the acute infection phase is not just restricted to the peripheral blood but also extends to other tissue compartments. However, in chronically infected individuals, heterogeneous and distinct viral populations were found in different compartments. We therefore conclude that the dominant and homogeneous viral population observed during the acute infection phase is likely to infiltrate lymphoid tissues and form the genetic bases for subsequent diversification. It is therefore likely that the compartmentalization of viral sequences observed in chronically infected patients reflects a gradual diversification of a common dominant viral variant rather than the preferential migration of distinct viral populations to different tissue compartments at the beginning of infection.

This article has been cited by other articles:

• Yang, C.-F., Chen, H.-Y., Jorba, J., Sun, H.-C., Yang, S.-J., Lee, H.-C., Huang, Y.-C., Lin, T.-Y., Chen, P.-J., Shimizu, H., Nishimura, Y., Utama, A., Pallansch, M., Miyamura, T., Kew, O., Yang, J.-Y. (2005). Intratypic Recombination among Lineages of Type 1 Vaccine-Derived Poliovirus Emerging during Chronic Infection of an Immunodeficient Patient. J. Virol. 79: 12623-12634 [Abstract] [Full Text]  
• Pillai, S. K., Good, B., Pond, S. K., Wong, J. K., Strain, M. C., Richman, D. D., Smith, D. M. (2005). Semen-Specific Genetic Characteristics of Human Immunodeficiency Virus Type 1 env. J. Virol. 79: 1734-1742 [Abstract] [Full Text]  
• Philpott, S., Burger, H., Tsoukas, C., Foley, B., Anastos, K., Kitchen, C., Weiser, B. (2005). Human Immunodeficiency Virus Type 1 Genomic RNA Sequences in the Female Genital Tract and Blood: Compartmentalization and Intrapatient Recombination. J. Virol. 79: 353-363 [Abstract] [Full Text]  
• Ewing, G., Nicholls, G., Rodrigo, A. (2004). Using Temporally Spaced Sequences to Simultaneously Estimate Migration Rates, Mutation Rate and Population Sizes in Measurably Evolving Populations. Genetics 168: 2407-2420 [Abstract] [Full Text]  
• Fulcher, J. A., Hwangbo, Y., Zioni, R., Nickle, D., Lin, X., Heath, L., Mullins, J. I., Corey, L., Zhu, T. (2004). Compartmentalization of Human Immunodeficiency Virus Type 1 between Blood Monocytes and CD4+ T Cells during Infection. J. Virol. 78: 7883-7893 [Abstract] [Full Text]  
• Tsui, R., Herring, B. L., Barbour, J. D., Grant, R. M., Bacchetti, P., Kral, A., Edlin, B. R., Delwart, E. L. (2004). Human Immunodeficiency Virus Type 1 Superinfection Was Not Detected following 215 Years of Injection Drug User Exposure. J. Virol. 78: 94-103 [Abstract] [Full Text]  
• Kemal, K. S., Foley, B., Burger, H., Anastos, K., Minkoff, H., Kitchen, C., Philpott, S. M., Gao, W., Robison, E., Holman, S., Dehner, C., Beck, S., Meyer, W. A. III, Landay, A., Kovacs, A., Bremer, J., Weiser, B. (2003). HIV-1 in genital tract and plasma of women: Compartmentalization of viral sequences, coreceptor usage, and glycosylation. Proc. Natl. Acad. Sci. USA 100: 12972-12977 [Abstract] [Full Text]  
• Poumbourios, P., Maerz, A. L., Drummer, H. E. (2003). Functional Evolution of the HIV-1 Envelope Glycoprotein 120 Association Site of Glycoprotein 41. J. Biol. Chem. 278: 42149-42160 [Abstract] [Full Text]