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Journal of Virology, September 2002, p. 9124-9134, Vol. 76, No. 18
0022-538X/02/$04.00+0     DOI: 10.1128/JVI.76.18.9124-9134.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Genetic Diversity within Human Erythroviruses: Identification of Three Genotypes

Annabelle Servant,1 Syria Laperche,2 Francis Lallemand,3 Valérie Marinho,1 Guillemette De Saint Maur,1 Jean François Meritet,4 and Antoine Garbarg-Chenon1*

Laboratoire de Virologie, Hôpital Armand Trousseau (EA2391, UFR Saint-Antoine),1 Institut National de la Transfusion Sanguine,2 Service de Maladies Infectieuses et Tropicales, Hôpital Rothschild,3 Laboratoire de Virologie, Hôpital Cochin-Saint Vincent de Paul (Université Paris 5), Paris, France4

Received 14 March 2002/ Accepted 2 June 2002

B19 virus is a human virus belonging to the genus Erythrovirus. The genetic diversity among B19 virus isolates has been reported to be very low, with less than 2% nucleotide divergence in the whole genome sequence. We have previously reported the isolation of a human erythrovirus isolate, termed V9, whose sequence was markedly distinct (>11% nucleotide divergence) from that of B19 virus. To date, the V9 isolate remains the unique representative of a new variant in the genus Erythrovirus, and its taxonomic position is unclear. We report here the isolation of 11 V9-related viruses. A prospective study conducted in France between 1999 and 2001 indicates that V9-related viruses actually circulate at a significant frequency (11.4%) along with B19 viruses. Analysis of the nearly full-length genome sequence of one V9-related isolate (D91.1) indicates that the D91.1 sequence clusters together with but is notably distant from the V9 sequence (5.3% divergence) and is distantly related to B19 virus sequences (13.8 to 14.2% divergence). Additional phylogenetic analysis of partial sequences from the V9-related isolates combined with erythrovirus sequences available in GenBank indicates that the erythrovirus group is more diverse than thought previously and can be divided into three well-individualized genotypes, with B19 viruses corresponding to genotype 1 and V9-related viruses being distributed into genotypes 2 and 3.

* Corresponding author. Mailing address: Laboratoire de Virologie, Hôpital Armand Trousseau, 26 Ave. du Dr. Arnold Netter, 75571 Paris Cedex 12, France. Phone: 33 1 4473 6281. Fax: 33 1 4473 6288. E-mail: a.chenon{at}trs.ap-hop-paris.fr.

Journal of Virology, September 2002, p. 9124-9134, Vol. 76, No. 18
0022-538X/02/$04.00+0     DOI: 10.1128/JVI.76.18.9124-9134.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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