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Journal of Virology, September 2002, p. 8973-8976, Vol. 76, No. 17
0022-538X/02/$04.00+0     DOI: 10.1128/JVI.76.17.8973-8976.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

The Vaccinia Virus I7L Gene Product Is The Core Protein Proteinase

Chelsea M. Byrd,1 Tove' C. Bolken,2 and Dennis E. Hruby2,3*

Molecular and Cellular Biology Program,1 Department of Microbiology, Oregon State University, Corvallis, Oregon 97331,3 SIGA Technologies, Inc., Corvallis, Oregon 973332

Received 4 April 2002/ Accepted 7 June 2002

Maturation of vaccinia virus (VV) core proteins is required for the production of infectious virions. The VV G1L and I7L gene products are the leading candidates for the viral core protein proteinase (vCPP). Using transient-expression assays, data were obtained to demonstrate that the I7L gene product and its encoded cysteine proteinase activity are responsible for vCPP activity.

* Corresponding author. Mailing address: SIGA Technologies, Inc., 4575 SW Research Way, Suite 230, Corvallis, OR 97333. Phone: (541) 737-1849. Fax: (541) 737-2440. E-mail: hrubyd{at}bcc.orst.edu.

Journal of Virology, September 2002, p. 8973-8976, Vol. 76, No. 17
0022-538X/02/$04.00+0     DOI: 10.1128/JVI.76.17.8973-8976.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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