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Journal of Virology, September 2002, p. 8548-8550, Vol. 76, No. 17
0022-538X/02/$04.00+0     DOI: 10.1128/JVI.76.17.8548-8550.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Naturally Acquired Simian Varicella Virus Infection in African Green Monkeys

Ravi Mahalingam,1 Vicki Traina-Dorge,2 Mary Wellish,1 John Smith,1 and Donald H. Gilden1,3*

Departments of Neurology,1 Microbiology, University of Colorado Health Sciences Center, Denver, Colorado 80262,3 Department of Microbiology, Tulane National Primate Research Center, Covington, Louisiana 704332

Received 29 March 2002/ Accepted 21 May 2002

Simian varicella virus (SVV) infection of primates shares clinical, pathological, immunological, and virological features with varicella-zoster virus infection of humans. Natural varicella infection was simulated by exposing four SVV-seronegative monkeys to monkeys inoculated intratracheally with SVV, in which viral DNA and RNA persist in multiple tissues for more than 1 year (T. M. White, R. Mahalingam, V. Traina-Dorge, and D. H. Gilden, J. Neurovirol. 8:191-205, 2002). The four naturally exposed monkeys developed mild varicella 10 to 14 days later, and skin scrapings taken at the time of the rash contained SVV DNA. Analysis of multiple ganglia, liver, and lung tissues from the four naturally exposed monkeys sacrificed 6 to 8 weeks after resolution of the rash revealed SVV DNA in ganglia at multiple levels of the neuraxis but not in the lung or liver tissue of any of the four monkeys. This animal model provides an experimental system to gain information about varicella latency with direct relevance to the human disease.

* Corresponding author. Mailing address: Department of Neurology, Mail Stop B182, University of Colorado Health Sciences Center, 4200 East 9th Ave., Denver, CO 80262. Phone: (303) 315-8281. Fax: (303) 315-8720. E-mail: don.gilden{at}uchsc.edu.

Journal of Virology, September 2002, p. 8548-8550, Vol. 76, No. 17
0022-538X/02/$04.00+0     DOI: 10.1128/JVI.76.17.8548-8550.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Sato, H., Pesnicak, L., Cohen, J. I. (2003). Varicella-Zoster Virus ORF47 Protein Kinase, Which Is Required for Replication in Human T Cells, and ORF66 Protein Kinase, Which Is Expressed during Latency, Are Dispensable for Establishment of Latency. J. Virol. 77: 11180-11185 [Abstract] [Full Text]  


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