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Journal of Virology, August 2002, p. 8468-8471, Vol. 76, No. 16
0022-538X/02/$04.00+0     DOI: 10.1128/JVI.76.16.8468-8471.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Glycoprotein I of Varicella-Zoster Virus Is Required for Viral Replication in Skin and T Cells

Jennifer Moffat,1* Hideki Ito,2 Marvin Sommer,2 Shannon Taylor,1 and Ann M. Arvin2

Department of Microbiology and Immunology, SUNY Upstate Medical University, Syracuse, New York,1 Departments of Pediatrics and Microbiology and Immunology, Stanford University, Stanford, California2

Received 8 April 2002/ Accepted 23 May 2002

Varicella-zoster virus (VZV) glycoprotein I (gI) is dispensable in cell culture; the SCIDhu model of VZV pathogenesis was used to determine whether gI is necessary in vivo. The parental and repaired viruses grew in human skin and thymus/liver implants, but the gI deletion mutant was not infectious. Thus, gI is essential for VZV infectivity in skin and T cells.

* Corresponding author. Mailing address: Department of Microbiology and Immunology, SUNY Upstate Medical University, 750 E. Adams St., Syracuse, NY 13210. Phone: (315) 464-5454. Fax: (315) 464-5465. E-mail: moffatj{at}mail.upstate.edu.

Journal of Virology, August 2002, p. 8468-8471, Vol. 76, No. 16
0022-538X/02/$04.00+0     DOI: 10.1128/JVI.76.16.8468-8471.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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