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 Previous Article

Journal of Virology, August 2002, p. 7918-7921, Vol. 76, No. 15
0022-538X/02/$04.00+0     DOI: 10.1128/JVI.76.15.7918-7921.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Resistance to Infection by Subgroups B, D, and E Avian Sarcoma and Leukosis Viruses Is Explained by a Premature Stop Codon within a Resistance Allele of the tvb Receptor Gene

Sara Klucking,1,2 Heather B. Adkins,3 and John A. T. Young1*

McArdle Laboratory for Cancer Research, University of Wisconsin—Madison, Madison, Wisconsin 53706,1 Committee on Virology, Division of Medical Sciences, Harvard Medical School, Boston, Massachusetts 02115,2 Biogen, Inc., Cambridge, Massachusetts 021423

Received 27 February 2002/ Accepted 5 May 2002

Here we present the first molecular characterization of the defect associated with an avian sarcoma and leukosis virus (ASLV) receptor resistance allele, tvbr. We show that resistance to infection by subgroups B, D, and E ASLV is explained by the presence of a single base pair mutation that distinguishes this allele from tvbs1, an allele which encodes a receptor for all three viral subgroups. This mutation generates an in-frame stop codon that is predicted to lead to the production of a severely truncated protein.

* Corresponding author. Mailing address: McArdle Laboratory for Cancer Research, University of Wisconsin—Madison, 1400 University Ave., Madison, WI 53706. Phone: (608) 265-5151. Fax: (608) 262-2824. E-mail: young{at}oncology.wisc.edu.

Journal of Virology, August 2002, p. 7918-7921, Vol. 76, No. 15
0022-538X/02/$04.00+0     DOI: 10.1128/JVI.76.15.7918-7921.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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