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Journal of Virology, August 2002, p. 7860-7862, Vol. 76, No. 15
0022-538X/02/$04.00+0     DOI: 10.1128/JVI.76.15.7860-7862.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

1917 Avian Influenza Virus Sequences Suggest that the 1918 Pandemic Virus Did Not Acquire Its Hemagglutinin Directly from Birds

Thomas G. Fanning,1* Richard D. Slemons,2 Ann H. Reid,1 Thomas A. Janczewski,1 James Dean,3 and Jeffery K. Taubenberger1

Division of Molecular Pathology, Department of Cellular Pathology and Genetics, Armed Forces Institute of Pathology, Rockville, Maryland 20850-3125,1 Department of Veterinary Preventive Medicine, College of Veterinary Medicine, Ohio State University, Columbus, Ohio 43210,2 Division of Birds, National Museum of Natural History, Washington, D.C. 205603

Received 29 January 2002/ Accepted 25 April 2002

Wild waterfowl captured between 1915 and 1919 were tested for influenza A virus RNA. One bird, captured in 1917, was infected with a virus of the same hemagglutinin (HA) subtype as that of the 1918 pandemic virus. The 1917 HA is more closely related to that of modern avian viruses than it is to that of the pandemic virus, suggesting (i) that there was little drift in avian sequences over the past 85 years and (ii) that the 1918 pandemic virus did not acquire its HA directly from a bird.

* *Corresponding author. Mailing address: Division of Molecular Pathology, Department of Cellular Pathology and Genetics, Armed Forces Institute of Pathology, 1413 Research Blvd., Building 101, Room 1057D, Rockville, MD 20850-3125. Phone: (301) 319-0303. Fax: (301) 295-9507. E-mail: fanning{at}afip.osd.mil.

Journal of Virology, August 2002, p. 7860-7862, Vol. 76, No. 15
0022-538X/02/$04.00+0     DOI: 10.1128/JVI.76.15.7860-7862.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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