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Journal of Virology, August 2002, p. 7855-7859, Vol. 76, No. 15
0022-538X/02/$04.00+0     DOI: 10.1128/JVI.76.15.7855-7859.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Handedness of the Herpes Simplex Virus Capsid and Procapsid

Naiqian Cheng,1 Benes L. Trus,1,2 David M. Belnap,1 William W. Newcomb,3 Jay C. Brown,3 and Alasdair C. Steven1*

Laboratory of Structural Biology, National Institute of Arthritis and Musculoskeletal and Skin Diseases,1 Computational Bioscience and Engineering Laboratory, Center for Information Technology, National Institutes of Health, Bethesda, Maryland 20892,2 Department of Microbiology, University of Virginia Health System, Charlottesville, Virginia 229083

Received 8 February 2002/ Accepted 19 April 2002

The capsid of herpes simplex virus has an icosahedral surface lattice with a nonskew triangulation number, T=16. Nevertheless, the proteins arrayed on this lattice necessarily have an intrinsic handedness. We have determined the handedness of both the herpes simplex virus type 1 capsid and its precursor procapsid by a cryoelectron microscopic tilting method.

* Corresponding author. Mailing address: Bldg. 50, Rm. 1517, MSC 8025, National Institutes of Health, Bethesda, MD 20892-8025. Phone: (301) 496-0132. Fax: (301) 480-7629. E-mail: Alasdair_Steven{at}nih.gov.

Journal of Virology, August 2002, p. 7855-7859, Vol. 76, No. 15
0022-538X/02/$04.00+0     DOI: 10.1128/JVI.76.15.7855-7859.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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