This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ramos, A.
Right arrow Articles by Subbarao, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ramos, A.
Right arrow Articles by Subbarao, S.

 Previous Article  |  Next Article 

Journal of Virology, August 2002, p. 7444-7452, Vol. 76, No. 15
0022-538X/02/$04.00+0     DOI: 10.1128/JVI.76.15.7444-7452.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Intersubtype Human Immunodeficiency Virus Type 1 Superinfection following Seroconversion to Primary Infection in Two Injection Drug Users

Artur Ramos,1 Dale J. Hu,1 Lily Nguyen,1 Kim-Oanh Phan,1,{dagger} Suphak Vanichseni,2 Nattawan Promadej,1 Kachit Choopanya,2 Margaret Callahan,1 Nancy L. Young,1,3 Janet McNicholl,1 Timothy D. Mastro,1,3 Thomas M. Folks,1 and Shambavi Subbarao1*

Centers for Disease Control and Prevention, Atlanta, Georgia,1 Bangkok Metropolitan Administration, Bangkok,2 Thai MOPH-US CDC Collaboration, Nonthaburi, Thailand3

Received 26 February 2002/ Accepted 6 May 2002

In this study, we describe two cases of human immunodeficiency virus type 1 (HIV-1) intersubtype superinfection with CRF01_AE and subtype B strains, which occurred in two injection drug users participating in a prospective cohort study in Bangkok, Thailand. In both cases, the superinfecting strain was detected by molecular and serologic analyses several weeks after complete seroconversion to the primary infection with a strain belonging to a different subtype. Superinfection occurred despite specific T-cell and humoral antibody responses to the primary virus. In both cases, cross-subtype immune responses were limited or absent prior to the second infection. These data show that, in some individuals, the quality and quantity of the immune response elicited by primary HIV-1 infection may not protect against superinfection. This finding has important implications for vaccine design. HIV-1 vaccines, at a minimum, will need to include potent, broadly protective, conserved immunogens derived from several group M subtypes.

* Corresponding author. Mailing address: Division of AIDS, STD, TB Laboratory Research (MS G-19), National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Rd., Atlanta, GA 30333. Phone: (404) 639-1397. Fax: (404) 639-1174. E-mail: Ssubbarao{at}cdc.gov.

{dagger} Present address: Accenture, Phoenix, AZ 85016.

Journal of Virology, August 2002, p. 7444-7452, Vol. 76, No. 15
0022-538X/02/$04.00+0     DOI: 10.1128/JVI.76.15.7444-7452.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Onafuwa-Nuga, A., Telesnitsky, A. (2009). The Remarkable Frequency of Human Immunodeficiency Virus Type 1 Genetic Recombination. Microbiol. Mol. Biol. Rev. 73: 451-480 [Abstract] [Full Text]  
  • Yeh, W. W., Jaru-ampornpan, P., Nevidomskyte, D., Asmal, M., Rao, S. S., Buzby, A. P., Montefiori, D. C., Korber, B. T., Letvin, N. L. (2009). Partial Protection of Simian Immunodeficiency Virus (SIV)-Infected Rhesus Monkeys against Superinfection with a Heterologous SIV Isolate. J. Virol. 83: 2686-2696 [Abstract] [Full Text]  
  • Blish, C. A., Dogan, O. C., Derby, N. R., Nguyen, M.-A., Chohan, B., Richardson, B. A., Overbaugh, J. (2008). Human Immunodeficiency Virus Type 1 Superinfection Occurs despite Relatively Robust Neutralizing Antibody Responses. J. Virol. 82: 12094-12103 [Abstract] [Full Text]  
  • Martcheva, M., Bolker, B. M, Holt, R. D (2008). Vaccine-induced pathogen strain replacement: what are the mechanisms?. J R Soc Interface 5: 3-13 [Abstract] [Full Text]  
  • Giannecchini, S., Pistello, M., Isola, P., Matteucci, D., Mazzetti, P., Freer, G., Bendinelli, M. (2007). Role of Env in Resistance of Feline Immunodeficiency Virus (FIV)-Infected Cats to Superinfection by a Second FIV Strain as Determined by Using a Chimeric Virus. J. Virol. 81: 10474-10485 [Abstract] [Full Text]  
  • Dykes, C., Wang, J., Jin, X., Planelles, V., An, D. S., Tallo, A., Huang, Y., Wu, H., Demeter, L. M. (2006). Evaluation of a multiple-cycle, recombinant virus, growth competition assay that uses flow cytometry to measure replication efficiency of human immunodeficiency virus type 1 in cell culture.. J. Clin. Microbiol. 44: 1930-1943 [Abstract] [Full Text]  
  • Deeks, S. G., Schweighardt, B., Wrin, T., Galovich, J., Hoh, R., Sinclair, E., Hunt, P., McCune, J. M., Martin, J. N., Petropoulos, C. J., Hecht, F. M. (2006). Neutralizing Antibody Responses against Autologous and Heterologous Viruses in Acute versus Chronic Human Immunodeficiency Virus (HIV) Infection: Evidence for a Constraint on the Ability of HIV To Completely Evade Neutralizing Antibody Responses.. J. Virol. 80: 6155-6164 [Abstract] [Full Text]  
  • Bergmeier, L.A., Lehner, T. (2006). Innate and Adaptive Mucosal Immunity in Protection against HIV Infection. ADR 19: 21-28 [Abstract] [Full Text]  
  • Galetto, R., Giacomoni, V., Veron, M., Negroni, M. (2006). Dissection of a Circumscribed Recombination Hot Spot in HIV-1 after a Single Infectious Cycle. J. Biol. Chem. 281: 2711-2720 [Abstract] [Full Text]  
  • McCutchan, F. E., Hoelscher, M., Tovanabutra, S., Piyasirisilp, S., Sanders-Buell, E., Ramos, G., Jagodzinski, L., Polonis, V., Maboko, L., Mmbando, D., Hoffmann, O., Riedner, G., von Sonnenburg, F., Robb, M., Birx, D. L. (2005). In-Depth Analysis of a Heterosexually Acquired Human Immunodeficiency Virus Type 1 Superinfection: Evolution, Temporal Fluctuation, and Intercompartment Dynamics from the Seronegative Window Period through 30 Months Postinfection. J. Virol. 79: 11693-11704 [Abstract] [Full Text]  
  • Chohan, B., Lavreys, L., Rainwater, S. M. J., Overbaugh, J. (2005). Evidence for Frequent Reinfection with Human Immunodeficiency Virus Type 1 of a Different Subtype. J. Virol. 79: 10701-10708 [Abstract] [Full Text]  
  • van Kesteren, N. M. C., Hospers, H. J., Kok, G., van Empelen, P. (2005). Sexuality and Sexual Risk Behavior in HIV-Positive Men Who Have Sex With Men. Qual Health Res 15: 145-168 [Abstract]  
  • Yang, O. O., Daar, E. S., Jamieson, B. D., Balamurugan, A., Smith, D. M., Pitt, J. A., Petropoulos, C. J., Richman, D. D., Little, S. J., Brown, A. J. L. (2005). Human Immunodeficiency Virus Type 1 Clade B Superinfection: Evidence for Differential Immune Containment of Distinct Clade B Strains. J. Virol. 79: 860-868 [Abstract] [Full Text]  
  • Haaft, P. t., Verschoor, E. J., Verstrepen, B., Niphuis, H., Dubbes, R., Koornstra, W., Bogers, W., Rosenwirth, B., Heeney, J. L. (2004). Readily acquired secondary infections of human and simian immunodeficiency viruses following single intravenous exposure in non-human primates. J. Gen. Virol. 85: 3735-3745 [Abstract] [Full Text]  
  • Tsui, R., Herring, B. L., Barbour, J. D., Grant, R. M., Bacchetti, P., Kral, A., Edlin, B. R., Delwart, E. L. (2004). Human Immunodeficiency Virus Type 1 Superinfection Was Not Detected following 215 Years of Injection Drug User Exposure. J. Virol. 78: 94-103 [Abstract] [Full Text]  
  • Pistello, M., Matteucci, D., Bonci, F., Isola, P., Mazzetti, P., Zaccaro, L., Merico, A., Del Mauro, D., Flynn, N., Bendinelli, M. (2003). AIDS Vaccination Studies Using an Ex Vivo Feline Immunodeficiency Virus Model: Protection from an Intraclade Challenge Administered Systemically or Mucosally by an Attenuated Vaccine. J. Virol. 77: 10740-10750 [Abstract] [Full Text]  
  • Abel, K., Compton, L., Rourke, T., Montefiori, D., Lu, D., Rothaeusler, K., Fritts, L., Bost, K., Miller, C. J. (2003). Simian-Human Immunodeficiency Virus SHIV89.6-Induced Protection against Intravaginal Challenge with Pathogenic SIVmac239 Is Independent of the Route of Immunization and Is Associated with a Combination of Cytotoxic T-Lymphocyte and Alpha Interferon Responses. J. Virol. 77: 3099-3118 [Abstract] [Full Text]  
  • Goulder, P. J.R., Walker, B. D. (2002). HIV-1 Superinfection -- A Word of Caution. NEJM 347: 756-758 [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»