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Journal of Virology, July 2002, p. 7329-7333, Vol. 76, No. 14
0022-538X/02/$04.00+0     DOI: 10.1128/JVI.76.14.7329-7333.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

CD4 T-Cell-Mediated Demyelination Is Increased in the Absence of Gamma Interferon in Mice Infected with Mouse Hepatitis Virus

Lecia Pewe,1 Jodie Haring,2 and Stanley Perlman1,2,3*

Departments of Pediatrics,1 Microbiology,2 Interdisciplinary Program in Immunology, University of Iowa, Iowa City, Iowa 522423

Received 6 March 2002/ Accepted 18 April 2002

Mice infected with the murine coronavirus, mouse hepatitis virus, strain JHM (MHV) develop an immune-mediated demyelinating encephalomyelitis. Adoptive transfer of MHV-immune splenocytes depleted of either CD4 or CD8 T cells to infected mice deficient in recombination activation gene 1 resulted in demyelination. We showed previously that the process of CD8 T-cell-mediated demyelination was strongly dependent on the expression of gamma interferon (IFN-{gamma}) by donor cells. In this report, we show, in contrast, that demyelination and lymphocyte infiltration were increased in recipients of IFN-{gamma}-/- CD4 T cells when compared to levels in mice receiving C57BL/6 CD4 T cells.

* Corresponding author. Mailing address: Department of Pediatrics, University of Iowa, Medical Laboratories 2042, Iowa City, IA 52242. Phone: (319) 335-8549. Fax: (319) 335-8991. E-mail: Stanley-Perlman{at}uiowa.edu.

Journal of Virology, July 2002, p. 7329-7333, Vol. 76, No. 14
0022-538X/02/$04.00+0     DOI: 10.1128/JVI.76.14.7329-7333.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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